Results 71 to 80 of about 683,284 (269)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence

npj Precision Oncology
Black men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision ...
Muthana Al Abo, Wen-Chi Foo, Lauren E. Howard, Shannon McGue, Bonnie Lacroix, Julie Kephart, Angela Clayton, Blair Thornburg, Monika Anand, Michael B. Rothberg, Shannon J. McCall, Jiaoti Huang, Thomas A. Esther, Judd W. Moul, Michael N. Ferrandino, Thomas J. Polascik, Cary N. Robertson, Brant A. Inman, Andrew J. Armstrong, Yuan Wu, Terry Hyslop, Daniel J. George, Steven R. Patierno, Jennifer A. Freedman   +23 more
doaj   +1 more source

First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients [PDF]

, 2012
Neil L. Berinstein, Mohan Karkada, Michael A. Morse, John Nemunaitis, Gurkamal Chatta, Howard L. Kaufman, Kunle Odunsi, Rita Nigam, Leeladhar Sammatur, Lisa D. MacDonald, Genevieve Weir, Marianne M. Stanford, Marc Mansour   +12 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by ¹⁸F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687 [PDF]

, 2015
Evan Y. Yu, Fenghai Duan, Mark Muzi, Xuan Deng, Bennett B. Chin, Joshi J. Alumkal, Mary-Ellen Taplin, Jina Taub, Ben Herman, Celestia S. Higano, Robert K. Doot, Donna Hartfeil, Philip G. Febbo, David A. Mankoff   +13 more
openalex   +1 more source

Uncovering prostate cancer aggressiveness signal in T2‐weighted MRI through a three‐reference tissues normalization technique

, 2023
Ahmad Algohary, Evangelia I. Zacharaki, Adrian Breto, Mohammad Alhusseini, Veronica Wallaengen, Isaac Xu, Sandra M. Gaston, Sanoj Punnen, Patricia Castillo, Pradip M. Pattany, Oleksandr N. Kryvenko, Benjamin Spieler, Matthew C. Abramowitz, Alan Dal Pra, John C. Ford, Alan Pollack, Radka Stoyanova   +16 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Combination therapy overcomes secondary PARPi resistance in ATM-deficient prostate cancer

npj Precision Oncology
PARP inhibitors (PARPi) are approved treatments for patients with metastatic prostate cancer (mPC); tumors with homologous recombination repair (HRR) defects are particularly sensitive to this drug class.
Sara Arce-Gallego, Victor Esquefa, Heura Domenech, Andrei Salca, Daniel Aguilar, Teresa Casals, Gisela Mir, Sara Simonetti, Anna Oliveira, Lara de Llobet, Antje Neeb, Julian Brandariz, Nicolas Anselmino, Irene Casanova-Salas, Nicolas Herranz, Violeta Serra, Johann S. de Bono, Joaquin Mateo   +17 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source