Results 231 to 240 of about 207,050 (299)

Novel Combination of Metronomic Cyclophosphamide and Darolutamide Induces Sustained Clinical Response in Heavily Treated Prostate Cancer with Prostate-Specific Membrane Antigen-Negative Liver Metastases and Rapid Disease Progression. [PDF]

Case Rep Oncol
Patel VM, Cai Q, Ahn R, Hill K, Wang J.
europepmc   +1 more source

Nodal maximum standardised uptake value improves PSMA‐PET/CT‐based nodal staging in intermediate‐ and high‐risk prostate cancer

BJU International, EarlyView.
Objectives To evaluate whether nodal maximum standardised uptake value (SUVmax) improves the positive predictive value (PPV) of prostate‐specific membrane antigen (PSMA) positron emission tomography (PET)/computerised tomography (CT) for detecting lymph node invasion (LNI) in prostate cancer (PCa), and to develop clinical decision tools to guide ...
Alexandra S. Bruins Slot, Vera Sweere, Joris G. Heetman, Rick Hermsen, Lieke Wever, Jules Lavalaye, Maarten Vinken, Clinton D. Bahler, Mark Tann, Claudia Kesch, Tugce Telli, Wolfgang P. Fendler, Peter Ka‐Fung Chiu, Kwan Kit Wu, Fabio Zattoni, Laura Evangelista, Francesco Ceci, Marcin Miszczyk, Pawel Rajwa, Akihiro Matsukawa, Tamás Fazekas, Francesco Barletta, Alberto Briganti, Francesco Montorsi, Giorgio Gandaglia, Jean‐Paul A. Van Basten, Harm H. E. Van Melick, Roderick C. N. Van den Bergh, Giancarlo Marra, Timo F. W. Soeterik, Matthijs J. V. Scheltema, on behalf of the European Association of Urology‐Young Academic Urologists (EAU‐YAU) Prostate Cancer Working Group   +31 more
wiley   +1 more source

Prostate-Specific Membrane Antigen-Targeted Antibody-Drug Conjugates: A Promising Approach for Metastatic Castration-Resistant Prostate Cancer. [PDF]

Cells
Shih CH, Hsieh TY, Sung WW.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Comparison of Prostate-specific Membrane Antigen Reporting and Data System Version 1.0 versus 2.0 for Prostate Cancer Assessment. [PDF]

Radiol Imaging Cancer
Almalki YE, Basha MAA, Ali SA, Donkol RH, Hamed MAG, Metwally MI, Hassan RMA, Frere RAF, Abdul Rahman AAE, Libda YI, Mahmoud NEM, Radwan MHSS, Eladl IM, Elsheikh AM, Zaitoun MMA, Mohamed Mohamed AS, AbdelHamid GA, Tantawy HF, Badr SE, Mosallam W, Al-Shatouri M, S Abo Shanab W, Dawoud TM, Khater HM, Abouelkheir RT, Abdelhamed H, Obaya AA, Elshafaay BS, Basha AMA, Mohammad RMA, Ebaid NY.   +30 more
europepmc   +1 more source

Extraperitoneal single‐site robot‐assisted radical prostatectomy with extended pelvic lymph node dissection: technique and experience

BJU International, Volume 135, Issue 4, Page 700-705, April 2025.
Yubo Wang, Mingzhao Li, Kai Yao, Zhuyinjun Zong, Yifan Chang, Yongda Liu, Chao Cai, Fadi Mousa Al Kalailah, Shancheng Ren, Guohua Zeng, Di Gu   +10 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Aiming High: Prostate-specific Membrane Antigen Expression in Treatment-naïve Prostate Cancer. [PDF]

Eur Urol
Bakht MK, Beltran H.
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Neovascular prostate specific membrane antigen (PSMA) expression in bone and soft tissue sarcoma: a systematic analysis. [PDF]

Virchows Arch
Spiridon IA, Ong SLM, Soukup J, Topirceanu-Andreoiu OM, de Geus-Oei LF, Gelderblom H, Lam SW, de Bruijn IHB, Akker BEWMVD, Hijmen L, Szuhai K, Bovée JVMG.   +11 more
europepmc   +1 more source