Results 91 to 100 of about 49,880 (236)
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei +9 more
wiley +1 more source
ABSTRACT Aims The detrimental impact of perioperative hyperglycaemia on surgical outcomes is well documented. However, economic evaluations on interventions to improve perioperative blood glucose management are lacking. This study aimed to assess the cost‐effectiveness of a multidisciplinary pre‐operative diabetes service compared with usual care in ...
Abby Yu +5 more
wiley +1 more source
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini +4 more
wiley +1 more source
Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer +4 more
wiley +1 more source
Prostate Cancer Development, Progression, and Therapy
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin +9 more
wiley +1 more source
ABSTRACT Introduction Erectile dysfunction (ED) significantly impacts quality of life. For patients unresponsive to conservative treatments, penile prosthesis implantation represents an effective solution with high satisfaction rates. However, the complexity and sensitive nature of the procedure often generate multiple patient concerns.
Gabriele Tulone +7 more
wiley +1 more source
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar +10 more
wiley +1 more source

