Results 131 to 140 of about 208,651 (377)

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

Postoperative complications of contemporary open and robot‐assisted laparoscopic radical prostatectomy using standardised reporting systems

BJU International, 2018
To analyse time trends and contemporary rates of postoperative complications after radical prostatectomy (RP) and to compare the complication profile of open RP (ORP) and robot‐assisted laparoscopic RP (RALP) using standardised reporting systems.
R. Pompe, B. Beyer, A. Haese*, F. Preisser, U. Michl, T. Steuber, M. Graefen, H. Huland, P. Karakiewicz, D. Tilki   +9 more
semanticscholar   +1 more source

Post‐Therapeutic Dosimetry of Metastatic Castration‐Resistant Prostate Cancer With 177Lu‐PSMA: Experiences From Two University‐Based Hospitals in Thailand

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Objective 177Lu‐PSMA radioligand therapy (RLT) is increasingly used to treat metastatic castration‐resistant prostate cancer (mCRPC). Posttreatment dosimetry is essential for assessing normal organ absorbed doses. Therefore, this study aims to evaluate normal organs dosimetry in mCRPC patients undergoing 177Lu‐PSMA‐RLT from two university ...
Onnicha Pattanawong, Putthiporn Charoenphun, Wichana Chamroonrat, Thonnapong Thongpraparn, Nucharee Poon‐iad, Benjapa Khiewvan, Krisanat Chuamsaamarkkee   +6 more
wiley   +1 more source

Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: Can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism? [PDF]

, 2016
Background: Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL).
Benjamin, Benji, Ellett, Stephanie, Ferguson, Lynnette R., Goudie, Megan, Han, Dug Yeo, Holmes, Michael, Karunasinghe, Nishi, Keogh, Justin, Lange, Katja, Masters, Jonathan, Wang, Alice, Zhu, Shuotun, Zhu, Yifei   +12 more
core   +2 more sources

Machine learning‐based classification of varicocoele grading: A promising approach for diagnosis and treatment optimization

Andrology, EarlyView.
Abstract Background Varicocoele is a correctable cause of male infertility. Although physical examination is still being used in diagnosis and grading, it gives conflicting results when compared to ultrasonography‐based varicocoele grading. Objectives We aimed to develop a multi‐class machine learning model for the grading of varicocoeles based on ...
Mehmet Vehbi Kayra, Ali Şahin, Serdar Toksöz, Mehmet Serindere, Emre Altıntaş, Halil Özer, Murat Gül   +6 more
wiley   +1 more source

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location [PDF]

, 2018
Background: Multiparametric magnetic resonance imaging (mpMRI) of the prostate appears to improve prostate cancer detection, but studies comparing mpMRI to histopathology at the time of radical prostatectomy (RP) are lacking.
Duncan, Ian, Goldman, Hariette, Harding, Catherine, McGirr, Joe, Seal, Alexa, Singh, Neha, Sowter, Steven   +6 more
core   +1 more source

Dupless: Toward a patient‐friendly approach for erectile dysfunction nature differentiation – a study of 291 penile duplex Doppler ultrasound assessments

Andrology, EarlyView.
Abstract Background Erectile dysfunction (ED) is a condition commonly classified as either psychogenic or organic. Traditional age‐based categorizations are considered overly simplistic, yet many clinicians continue to rely on initial evaluation—patient symptoms and history, physical examination, blood tests, and questionnaires—for diagnosis due to ...
Hille J. Torenvlied, Kim E. de Jager, Loes I. Segerink, Rob C. M. Pelger, Jack J. H. Beck   +4 more
wiley   +1 more source

Genomic biomarkers in prostate cancer. [PDF]

, 2018
Prostate cancer is the most common non-cutaneous cancer among men in the United States. In the last decade there has been a rapid expansion in the field of biomarker assays for diagnosis, prognosis, and treatment prediction in prostate cancer.
Cooperberg, Matthew R, Feng, Felix Y, Kornberg, Zachary, Spratt, Daniel E   +3 more
core  

The effect of topical and intraurethral alprostadil on erectile function: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Erectile dysfunction (ED) affects up to 50% of men over 40. While phosphodiesterase‐5 inhibitors (PDE5i) are the first line of medical treatment, they are not always effective. Alprostadil, available in injectable, topical, and intraurethral forms, offers an alternative treatment modality.
Iason Papadopoulos, Maksim Tishukov, Ioannis Sokolakis, Ioannis Katafigiotis, Ioannis Leotsakos, Markos Karavitakis, Julian Marcon, Christian G Stief, Nikolaos Pyrgidis   +8 more
wiley   +1 more source

Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. [PDF]

, 2019
Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT).
Agarwal, Priyanka, Angara, Bryan, Bhowmick, Neil A, Billet, Sandrine, Duong, Frank, Haldar, Subhash, Hickok, David, Kato, Manabu, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Placencio-Hickok, Veronica R, Rohena-Rivera, Krizia, Smith, Bethany, Tripathi, Manisha   +14 more
core   +1 more source