Results 21 to 30 of about 15,814 (254)

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes

Nature Communications, 2022
Activation of the androgen receptor (AR) through androgen binding is essential for prostate tumorigenesis. Here the authors show that AR activation in a subpopulation of prostatic progenitor cells can initiate prostatic intraepithelial neoplasia ...
Won Kyung Kim, Adam W. Olson, Jiaqi Mi, Jinhui Wang, Dong-Hoon Lee, Vien Le, Alex Hiroto, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Robert Cardiff, Sungyong You, Zijie Sun   +12 more
doaj   +1 more source

Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. [PDF]

PLoS ONE, 2013
The inhibitor of apoptosis protein survivin is expressed in most cancers. Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth.
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B Cohen, Shili Xu, Nouri Neamati, Edward M Conway, Chieh-Yang Cheng, Alexander Yu Nikitin, Pradip Roy-Burman   +10 more
doaj   +1 more source

The human gastrointestinal microbiota and prostate cancer development and treatment [PDF]

, 2020
The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment.
Alanee, Alexander, Althuis, Amirian, Arthur, Bostwick, Boursi, Buti, Cheng, Cimadamore, Cockburn, Costello, Cuevas-Ramos, Daniels, De Marzo, De Marzo, Dennis, Dominguez-Bello, Eckburg, Elkahwaji, Elkrief, Figueiredo, Gill, Golombos, Goodman, Graessler, Haller, Hamada, Hatakeyama, Hunter, Iida, Kamps, Lampe, Lara-Tejero, Lenoir, Liss, Masood, Meldrum, Miquel, Miyake, Montassier, Mosca, Mouraviev, Musso, Nakai, O'Hara, Olsson, Paulos, Plottel, Porter, Poutahidis, Punnen, Qin, Redman, Ridlon, Roberts, Roy, Russell, Sfanos, Siegel, Smith, Sokol, Sokol, Sonn, The Global Cancer Observatory, Tulstrup, Vande Voorde, Viaud, Vivarelli, Vétizou, Wilson   +70 more
core   +1 more source

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression. [PDF]

, 2015
Most men diagnosed with prostate cancer will have an indolent and curable disease, whereas approximately 15% of these patients will rapidly progress to a castrate-resistant and metastatic stage with high morbidity and mortality.
Albo, Giancarlo, Altieri, Dario C, Bosari, Silvano, Del Nero, Alberto, Ferrero, Stefano, Forno, Irene, Gazzano, Giacomo, Giangiobbe, Sara, Languino, Lucia R, Montanari, Emanuele, Rocco, Bernardo, Russo, Maria Veronica, Vaira, Valentina   +12 more
core   +17 more sources

Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma [PDF]

, 2006
The aim of the present study was to correlate the presence and extent of retraction clefting and the expression of p63 in neoplastic glands and glands with prostatic intraepithelial neoplasia (PIN) in needle core biopsies.
Belicza, Mladen, Cviko, Aida, Krušlin, Božo, Odak, Ljubica, Tomas, Davor, Čupić, Hrvoje   +5 more
core   +1 more source

5α-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores. [PDF]

PLoS ONE, 2017
The contribution of 5α-reductase 1 and 5α-reductase 2 to prostate cancer development and progression is not clearly understood. TRAMP mice are a common prostate cancer model, in which 5α-reductase 1 and 5α-reductase 2 expression levels, along with ...
Alexander B Opoku-Acheampong, Jamie N Henningson, Amanda P Beck, Brian L Lindshield   +3 more
doaj   +1 more source

Death receptor 5 expression is inversely correlated with prostate cancer progression. [PDF]

, 2014
Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic
Antonio-Andres, Gabriela, Bonavida, Benjamin, Gonzalez-Bonilla, Cesar, Hernandez-Cueto, Angeles, Hernandez-Cueto, Daniel, Huerta-Yepez, Sara, Jimenez-Gutierrez, Carlos, Mendoza-Marin, Marisela, Mora-Campos, Rosario, Sandoval-Mejia, Ana Lilia, Vega, Mario I   +10 more
core   +1 more source

Clinicopathological Study of Prostatic Biopsies [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Prostatism is a common malady in the geriatric age group. Benign prostatic hyperplasia and Carcinoma of the prostate are increasingly frequent with advancing age. The aim of the present study is to study the spectrum of prostatic lesions
A.JOSEPHINE
doaj   +1 more source

Prostatic adenocarcinoma with a peculiar morphology – a rare case of pseudohyperplastic variant with inverted polarity

Surgical and Experimental Pathology, 2022
Background The inverted (hobnail) variant of high-grade prostatic intraepithelial neoplasia (HGPIN) has been reported in two previous series and one case of inverted polarity in invasive adenocarcinoma has been reported. We reported an additional case of
Daniel Abensur Athanazio, Maiara Ferreira de Souza, Maria Estela Pompeu do Amaral   +2 more
doaj   +1 more source

Hepsin immunohistochemical expression in prostate cancer in relation to Gleason′s grade and serum prostate specific antigen

Indian Journal of Pathology and Microbiology, 2011
Background: Hepsin (HPN), a type II trans-membrane serine protease, has been reported to be one of the most up regulated genes in prostate cancer. The aim of the present study was to find out immuno-histochemistry based phenotypic expression of HPN in ...
Madhu Mati Goel, Dhamita Agrawal, S M Natu, Apul Goel   +3 more
doaj   +1 more source