Results 1 to 10 of about 11,295 (242)
Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 A better understanding of the early stages of prostate cancer initiation, potentially arising from precursor lesions, may fuel development of powerful approaches for prostate cancer prevention or interception. The best-known candidate for such a precursor lesion has been referred to as high-grade prostatic intraepithelial neoplasia (HGPIN).
Levent Trabzonlu +12 more
europepmc +6 more sources
Interobserver Variability in the Diagnosis of High-Grade Prostatic Intraepithelial Neoplasia in a Tertiary Hospital in Northern Jordan [PDF]
Clinical Pathology, 2020 Prostate intraepithelial neoplasia is described as a precursor lesion to prostatic adenocarcinoma. High-grade prostate intraepithelial neoplasia (HGPIN) is classified as both grade 2 and 3 prostate intraepithelial neoplasia due to inconsistency between ...
Najla Aldaoud +5 more
doaj +2 more sources
High-Grade Prostatic Intraepithelial Neoplasia [PDF]
Korean Journal of Urology, 2012 High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing ...
Klink, Joseph C +3 more
openaire +3 more sources
ERG expression in prostate cancer biopsies with and without high-grade prostatic intraepithelial neoplasia: a study in Jordanian Arab patients [PDF]
Research and Reports in Urology, 2019 Najla Aldaoud,1,2 Ashley Graboski-Bauer,3 Nour Abdo,4 Samir Al Bashir,1,2 Ashraf O Oweis,5 Hanadi Ebwaini,1 Yousef Hasen,1–2,6 Rami Alazab,7 Kiril Trpkov81Department of Pathology and Microbiology, King Abdullah University Hospital, Irbid, Jordan ...
Aldaoud N +8 more
doaj +2 more sources
Alteration of proliferation and apoptotic markers in normal and premalignant tissue associated with prostate cancer [PDF]
BMC Cancer, 2006 Background Molecular markers identifying alterations in proliferation and apoptotic pathways could be particularly important in characterizing high-risk normal or pre-neoplastic tissue. We evaluated the following markers: Ki67, Minichromosome Maintenance
Yang Ximing J +4 more
doaj +4 more sources
Journal of the Egyptian National Cancer Institute, 2013 Background: Histopathological differentiation between BCH and HGPIN in prostatic needle biopsies is a diagnostic challenge. The gold standard for detection of HGPIN and BCH is histopathological examination; however subjectivity in interpretation and tiny
Fatma El‐Zahraa Salah El‐Deen Yassin +4 more
openalex +3 more sources
Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma [PDF]
Vojnosanitetski Pregled, 2007 Background/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity.
Ljubinka Janković Veličković +3 more
openalex +3 more sources
Neoplasia: An International Journal for Oncology Research, 2007 The causes of early genomic events underlying the development of prostate cancer (CaP) remain unclear. The onset of chromosomal instability is likely to facilitate the formation of crucial genomic aberrations both in the precursor lesion high-grade ...
Anthony M. Joshua +7 more
openalex +3 more sources
High-grade prostatic intraepithelial neoplasia [PDF]
Modern Pathology, 2004 High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method
David G, Bostwick, Junqi, Qian
openaire +3 more sources
Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia [PDF]
Korean Journal of Urology, 2015 To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN).We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive ...
Lee, Donghyun +7 more
openaire +3 more sources