Results 41 to 50 of about 15,890 (255)

Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity.
Janković-Veličković Ljubinka, Đorđević Biljana, Rančić Gorana, Marjanović Goran   +3 more
doaj   +1 more source

A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma [PDF]

, 2017
Aims: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC.
Adamczyk, Lukasz A., Cullen, Jayne, Evans, Shanna, Oien, Karin A., Oniscu, Anca, Wong, Newton A.C.S.   +5 more
core   +1 more source

MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia [PDF]

, 2018
OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers ...
Bordi, G, Carico, E, Caserta, D, DE VITIS, C, DI PROPERZIO, M, Giglio, S, Lukic, A, Mancini, R.   +7 more
core   +1 more source

Overexpression of MiR-155-5p and increased number of macrophage population in precancerous prostatic disease

Health Science Journal of Indonesia, 2020
Latar Belakang: Gangguan regulasi mikroRNA(miR) dan inflamasi kronik dapat mengubah tumor menjadi karsinoma dan kanker dengan metastasis melalui perubahan seluler dan genomik. Lesi prekanker memiliki peluang 33,3 persen menjadi kanker.
Rachma Greta Putri, Sari Eka Pratiwi, Didik Setyo Heriyanto, Danarto Danarto, Indwiani Astuti, Nur Arfian, Sofia Mubarika Haryana   +6 more
doaj   +1 more source

Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload. [PDF]

, 2020
Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and ...
Ayyagari, Devi, Bonham, Michael J., Chamarthi, Ramachandra Vikas, Cockerell, Clay J., Feeser, Theresa A., Ianni, Julianna D., Lee, Jason B., Motaparthi, Kiran, Olsen, Thomas G., Sankarapandian, Sivaramakrishnan, Soans, Rajath E., Stavish, Coleman C.   +11 more
core   +1 more source

Predicting prostate biopsy outcome: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) are useful biomarkers [PDF]

, 2012
Indication for prostate biopsy is presently mainly based on prostate-specific antigen (PSA) serum levels and digital-rectal examination (DRE). In view of the unsatisfactory accuracy of these two diagnostic exams, research has focused on novel markers to ...
A. D. Carlo, A. Mariano, A. Marino, A. Sorrentino, BRUZZESE, DARIO, C. Buonerba, C. Mazzarella, G. D. Lorenzo, M. Ferro, R. Autorino, S. Perdonà, TERRACCIANO, DANIELA, V. Altieri, V. Macchia   +13 more
core   +1 more source

Ki-67 immunolabeling in pre-malignant lesions and carcinoma of the prostate. Histological correlation and prognostic evaluation

European Journal of Histochemistry, 2009
The antigen Ki-67, which is associated with cell proliferation, has been demonstrated to be useful in predicting the development of human tumors. The objective of this study was to evaluate the prognostic utility of this biomarker in pre-malignant and ...
E Muñoz, F Gómez, JI Paz, I Casado
doaj   +1 more source

Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer [PDF]

, 2013
Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation.
Amado, Francisco, Baptista, Tiago, Costa, Natália R., Costa-Pinheiro, Pedro, Henrique, Rui, Jerónimo, Carmen, Oliveira, Ana Isabel, Pinho dos Santos Graça, Maria Inês, Sousa, Elsa Joana   +8 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source