High-grade prostatic intraepithelial neoplasia [PDF]
Modern Pathology, 2004 High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method
David G, Bostwick, Junqi, Qian
openaire +2 more sources
uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS
Ciência Animal Brasileira, 2013 Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential.
Mariana Rodrigues Faleiro +6 more
doaj +3 more sources
Türk Patoloji Dergisi, 2018 Objective: Deviations in the apoptotic process have been demonstrated in prostate carcinogenesis. We aimed to evaluate especially the process of extrinsic apoptosis in the spectrum of neoplastic lesions of the prostate epithelium so as to reveal the ...
Ayşe Burcu İLERİ +5 more
doaj +1 more source
Prostatic intraepithelial neoplasia- the story evolves
Journal of Pathology of Nepal, 2016 Prostatic intraepithelial neoplasia is preneoplastic lesion described from early of this 20th century. PIN includes a spectrum of features ranging from low grade to high grade neoplasia. The studies are focused on their influence to predict the occurence
SV Pradhan, P Sharan
doaj +1 more source
Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells [PDF]
, 2012 DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and metastasis.
D'Alessandro, Anna Maria +9 more
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Predicting prostate biopsy outcome: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) are useful biomarkers [PDF]
, 2012 Indication for prostate biopsy is presently mainly based on prostate-specific antigen (PSA) serum levels and digital-rectal examination (DRE). In view of the unsatisfactory accuracy of these two diagnostic exams, research has focused on novel markers to ...
A. D. Carlo +13 more
core +1 more source
MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia [PDF]
, 2018 OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers ...
Bordi, G +7 more
core +1 more source
The use of immunohistochemistry for diagnosis of prostate cancer [PDF]
, 2010 PURPOSE: Atypical glands (ASAP) are diagnosed in 5.0% of prostate biopsies, and cancer identification in a rebiopsy is higher than 40.0%. The use of antibodies to mark basal cells is currently a common practice, in order to avoid rebiopsies.
ANTUNES, Alberto A. +7 more
core +2 more sources
The diagnostic importance of biomarkers of angio-genesis and inflammation at patients with prostate diseases [PDF]
Саратовский научно-медицинский журнал, 2016 Purpose: to establish the nature of change of the maintenance of PSA and markers of angiogenesis and inflammation in blood serum at patients with prostate diseases. Material and Methods.
Popkov V.M. +3 more
doaj
Senescence controls prostatic neoplasia driven by Pten loss
Molecular & Cellular Oncology, 2019 We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia.
Maxime Parisotto +3 more
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