Results 171 to 180 of about 80,244 (264)

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Radical prostatectomy in metastatic prostate cancer: is there enough evidence? | Opinion: Yes

International Brazilian Journal of Urology
Walter Henriques da Costa, Gustavo Cardoso Guimarães   +1 more
doaj   +1 more source

Araticum (Annona crassiflora) seed extract as a chemopreventive agent against prostate cancer: activation of extrinsic and intrinsic apoptotic pathways in a preclinical model. [PDF]

J Mol Histol
Lemos IL, Macedo MJ, Santos FR, Rezende BB, Montico F, Cagnon VHA, Junior MRM.   +6 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Most of patients with localized prostate cancer will be treated in the future? | Opinion: Yes

International Brazilian Journal of Urology
Paolo Dell’Oglio, Rafael Sanchez-Salas
doaj   +1 more source

Renal-Type Clear Cell Carcinoma of the Prostate: A Histopathological Case Report of a Rare and Underrecognized Variant. [PDF]

Reports (MDPI)
Stoyanov G, Marchev D, Pavlov P, Popov H.   +3 more
europepmc   +1 more source

Two-Stage Micturition as a Clue to Giant Inguinoscrotal Bladder Herniation: A Rare Diagnostic Pitfall. [PDF]

Cureus
Ameur Y, Zhim M, Oukouhou A, Sobhi A, Hamedoun L, Tetou M, Mrabti M, Boukhlifi Y, El Bahri A, Alami M, Ameur A.   +10 more
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

A Rare Presentation of Benign Prostatic Hyperplasia With Pure Stromal Hyperplasia as a Large Isolated Pelvic Mass With Normal Prostate Imaging. [PDF]

Int J Surg Pathol
Ren D, Houshyar R, Edwards RA.
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source