Results 51 to 60 of about 802,667 (378)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

A new modification of the chiron ACS assay for total prostate-specific antigen achieves equimolar response characteristics and improves the detection of prostate cancer [PDF]

, 2003
Nonequimolar-response assays for prostate-specific antigen (PSA) are criticized for overestimating total PSA in some men without prostate cancer (PCA), and underestimating total PSA in some men with PCA.
Brandt, Burkhard, De Angelis, Gabriela, Hamm, Michael, Heinecke, Achim, Hertle, Lothar, Oberpenning, Frank, Schmid, Hans-Peter, Semjonow, Axel, Stieber, Petra, Weining, Christoph   +9 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Serving as a bedside surgeon before performing robotic radical prostatectomy improves surgical outcomes [PDF]

International Brazilian Journal of Urology, 2019
Introduction: To evaluate the influence of previous experience as bedside assistants on patient selection, perioperative and pathological results in robot assisted laparoscopic radical prostatectomy.
Haci Ibrahim Cimen, Yavuz Tarik Atik, Deniz Gul, Burak Uysal, Mevlana Derya Balbay   +4 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Twenty-two-year incidence trend of urological cancers in the Republic of Korea: 1999–2020 [PDF]

Investigative and Clinical Urology
Purpose: Cancer is a disease with high social costs, and policymaking through accurate statistics is very important. This study presents the national cancer statistics on the incidence of urological cancers in the Republic of Korea over 22 years, from ...
Seunghyeon Cho, Won-Ju Park
doaj   +1 more source

A Prostate Neoplasm Distantly Metastasized to the Unilateral Ureter

Korean Journal of Urology, 2007
72세 남자 환자가 배뇨곤란, 빈뇨, 야간뇨, 세뇨 등의 하 부요로증상으로 본원 비뇨기과를 방문하였다. 과거력에서 당뇨병이 있었으며 가족력에서 특이사항은 없었다. 신체검 사에서 전신상태는 양호하였으며 활력징후는 정상이었다. 직장수지검사에서 전립선은 중등도 이상의 대칭적 비대를 보였으나 결절은 만져지지 않았고 표면은 우측엽에서 약간 불규칙한 양상을 나타냈다. 일반혈액검사 및 혈액화학검사 는 정상이었고, 일반 요검사에서 적혈구와 백혈구가 고배 율 시야에서 1-4개가 관찰되었다.
Mee Joo, Deuk Jung Yong, In Rae Cho, Jong Gu Kim, Keon-Cheol Lee   +4 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Genomic and proteomic profiling for cancer diagnosis in dogs [PDF]

, 2016
Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in ...
Morris, Joanna S.
core   +1 more source

Report of Frequency of Prostatic Adenocarcinoma Stage A in Patients Operated due to BPH

پزشکی بالینی ابن سینا, 2003
In this study 1192 cases were studied from 1986 to1996 in Imam Khomeini and Ekbatan hospitals of Hamadan province.           75 cases were found having pathologic stage A cancer (occult cancer).
Hooshang
doaj