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Property-based optimisation of PROTACs

RSC Medicinal Chemistry
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical properties.
James S. Scott   +2 more
openaire   +2 more sources

PROTACs for prostate cancer

Nature Reviews Urology, 2023
openaire   +2 more sources

Developing antibody-based PROTACs

Nature Reviews Drug Discovery, 2022
openaire   +2 more sources

A PROTAC for ALL

Nature Reviews Drug Discovery, 2022
openaire   +2 more sources

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Nature Aging
Yang Yang   +15 more
semanticscholar   +1 more source

Delivery Systems: Miniaturised PROTAC, Nano PROTAC, and Aptamer-Based RNA PROTAC

Manish P. Patel   +5 more
openaire   +1 more source

PROTACing against liver cancer

Nature Reviews Cancer
openaire   +2 more sources

Protac tissue distribution

Drug Metabolism and Pharmacokinetics
Stefanus Steyn   +4 more
openaire   +1 more source

Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

Acta Pharmacologica Sinica
Zhifeng Zou   +10 more
semanticscholar   +1 more source

La technologie PROTAC

médecine/sciences
Marina Azuaga Moreso   +7 more
openaire   +1 more source
targeted protein degradation
protein degradation
ubiquitin-proteasome system
science
degradation
cancer therapy
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