Results 211 to 220 of about 11,341 (256)

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation. [PDF]

J Am Chem Soc
Frost A, O'Connor S, Ciulli A.
europepmc   +1 more source

Targeting the ubiquitin-proteasome system and drug therapy in colorectal cancer. [PDF]

J Mol Cell Biol
Su R, Shao Y, Wang Q, Liu D, Wang Y, Kong D, Qiu Y.   +6 more
europepmc   +1 more source

Dual tumor microenvironment-responsive albumin nanoplatform integrates conditional PROTAC activation with starvation and ferroptosis for synergistic cancer therapy. [PDF]

J Nanobiotechnology
Lin L, Chen B, Yang Y, Deng R, Niu W, Liu J, Xu W, Li H.   +7 more
europepmc   +1 more source

Development of Trivalent PROTACs Based on BRD4-targeting PROTACs

Development of Trivalent PROTACs Based on BRD4-targeting PROTACs
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The therapeutic potential of PROTACs

Expert Opinion on Therapeutic Patents, 2021
PROTACs represent a novel class of heterobifunctional molecules that simultaneously bind to a target protein and to an E3 ligase complex, resulting in the transfer of ubiquitin and initiating a process ultimately causing the proteasomal degradation of the target protein.
Andrew B, Benowitz, Katherine L, Jones, John D, Harling   +2 more
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The application of PROTAC in HDAC

European Journal of Medicinal Chemistry, 2023
Inducing protein degradation by proteolysis targeting chimera (PROTAC) has provided great opportunities for scientific research and industrial applications. Histone deacetylase (HDAC)-PROTAC has been widely developed since the first report of its ability to induce the degradation of SIRT2 in 2017.
Shaoting Chen, Yuxiang Zheng, Benji Liang, Yudong Yin, Jian Yao, Quande Wang, Yanghan Liu, Nouri Neamati   +7 more
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Controlling PROTACs with Light

ChemMedChem, 2020
AbstractProteolysis targeting chimeras, PROTACs, are emerging as a powerful strategy for exerting exogenous control over protein levels, allowing small molecules to exploit the ubiquitin–proteasome pathway for targeted protein degradation. This highlight focuses on the fusion of photochemistry with these bifunctional compounds, which has provided a ...
Shreya Verma, Debasish Manna
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PROTACs: past, present and future

Chemical Society Reviews, 2022
This review highlights important milestones in the evolution of PROTACs, briefly discusses recent lessons about targeted protein degradation, and conjectures on the efforts still needed to expand the toolbox for PROTAC discovery.
Ke Li, Craig M. Crews
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