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Poxvirus Exploitation of the Ubiquitin-Proteasome System [PDF]

Viruses, 2010
Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been
Alastair Teale, Qian Wang, Kristin Burles, Michele Barry, Kelly Mottet, Nicholas van Buuren   +5 more
doaj   +5 more sources

Targeting the Ubiquitin–Proteasome System for Cancer [PDF]

MedComm
Ubiquitin is a highly conserved small molecule that exists in large quantities in eukaryotic cells and plays a crucial role in protein quality control by phagocytosis and degradation of ubiquitin‐modified proteins.
Zhaoyun Liu, Jiao Lai, Ziyu Ma, Jianhua Pan, Chun Yang, Rong Fu   +5 more
doaj   +2 more sources

Intracellular Dynamics of the Ubiquitin-Proteasome-System [v1; ref status: indexed, http://f1000r.es/5o5] [PDF]

F1000Research, 2015
The ubiquitin-proteasome system is the major degradation pathway for short-lived proteins in eukaryotic cells. Targets of the ubiquitin-proteasome-system are proteins regulating a broad range of cellular processes including cell cycle progression, gene ...
Maisha Chowdhury, Cordula Enenkel
doaj   +4 more sources

Ubiquitin Proteasome System in Stress and Disease [PDF]

Biochemistry Research International, 2012
The proteasome is an ATP-dependent multisubunit self-compartmentalised protease complex. It is the major regulator of intracellular proteins turnover. The majority of proteins degraded by proteasomes are modified by covalent attachment of polyubiquitin chains.
Dmitry Karpov, Michael H. Glickman, Shoshana Bar-Nun, Philip Coffino   +3 more
doaj   +4 more sources

Ubiquitin proteasome system in cardiac fibrosis [PDF]

Journal of Advanced Research
Background: Cardiac fibrosis, including reactive fibrosis and replacement fibrosis, is a common pathological process in most cardiovascular diseases.
Linqi Zeng, Xiaokai Zhang, Zihang Huang, Shuai Song, Mohan Li, Tongyao Wang, Aijun Sun, Junbo Ge   +7 more
doaj   +2 more sources

Human Viral Oncoproteins and Ubiquitin–Proteasome System [PDF]

Global Medical Genetics
Some human cancers worldwide may be related to human tumor viruses. Knowing, controlling, and managing the viruses that cause cancers remain a problem.
Zahra Rafiei Atani, Sareh Sadat Hosseini, Hossein Goudarzi, Ebrahim Faghihloo   +3 more
doaj   +2 more sources

Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis

Frontiers in Molecular Biosciences, 2023
To counteract proteotoxic stress and cellular aging, protein quality control (PQC) systems rely on the refolding, degradation and sequestration of misfolded proteins.
Areeb Jawed, Areeb Jawed, Chi-Ting Ho, Chi-Ting Ho, Tomas Grousl, Tomas Grousl, Aseem Shrivastava, Aseem Shrivastava, Thomas Ruppert, Bernd Bukau, Bernd Bukau, Axel Mogk, Axel Mogk   +12 more
doaj   +1 more source

Chlorogenic acid modulates the ubiquitin–proteasome system in stroke animal model

Laboratory Animal Research, 2022
Background Chlorogenic acid, a phenolic compound, has potent antioxidant and neuroprotective properties. The ubiquitin–proteasome system is an important regulators of neurodevelopment and modulators of neuronal function.
Murad-Ali Shah, Ju-Bin Kang, Phil-Ok Koh
doaj   +1 more source

Substrate-specific effects of natural genetic variation on proteasome activity.

PLoS Genetics, 2023
Protein degradation is an essential biological process that regulates protein abundance and removes misfolded and damaged proteins from cells. In eukaryotes, most protein degradation occurs through the stepwise actions of two functionally distinct ...
Mahlon A Collins, Randi Avery, Frank W Albert   +2 more
doaj   +1 more source

Targeted Protein Degradation: Principles and Applications of the Proteasome

Cells, 2023
The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities).
Yosup Kim, Eun-Kyung Kim, Yoona Chey, Min-Jeong Song, Ho Hee Jang   +4 more
doaj   +1 more source