Results 1 to 10 of about 17,362,245 (308)

Ubiquitin-proteasome system in diabetic retinopathy [PDF]

PeerJ, 2022
Diabetic retinopathy (DR) is the most common complication of diabetes, being the most prevalent reason for blindness among the working-age population in the developed world.
Zane Svikle, Beate Peterfelde, Nikolajs Sjakste, Kristine Baumane, Rasa Verkauskiene, Chi-Juei Jeng, Jelizaveta Sokolovska   +6 more
doaj   +5 more sources

Targeting the Ubiquitin–Proteasome System for Cancer [PDF]

MedComm
Ubiquitin is a highly conserved small molecule that exists in large quantities in eukaryotic cells and plays a crucial role in protein quality control by phagocytosis and degradation of ubiquitin‐modified proteins.
Zhaoyun Liu, Jiao Lai, Ziyu Ma, Jianhua Pan, Chun Yang, Rong Fu   +5 more
doaj   +2 more sources

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

Open Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska   +2 more
doaj   +3 more sources

The Ubiquitin–Proteasome System in Immune Cells

Biomolecules, 2021
The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is ...
Gonca Çetin, Sandro Klafack, Maja Studencka-Turski, Elke Krüger, Frédéric Ebstein   +4 more
doaj   +3 more sources

Ubiquitin Proteasome System in Stress and Disease [PDF]

Biochemistry Research International, 2012
The proteasome is an ATP-dependent multisubunit self-compartmentalised protease complex. It is the major regulator of intracellular proteins turnover. The majority of proteins degraded by proteasomes are modified by covalent attachment of polyubiquitin chains.
Dmitry Karpov, Michael H. Glickman, Shoshana Bar-Nun, Philip Coffino   +3 more
doaj   +4 more sources

Ubiquitin proteasome system in cardiac fibrosis [PDF]

Journal of Advanced Research
Background: Cardiac fibrosis, including reactive fibrosis and replacement fibrosis, is a common pathological process in most cardiovascular diseases.
Linqi Zeng, Xiaokai Zhang, Zihang Huang, Shuai Song, Mohan Li, Tongyao Wang, Aijun Sun, Junbo Ge   +7 more
doaj   +2 more sources

The Ubiquitin-Proteasome System Plays Dual Roles in Plant Antiviral Defense and Viral Pathogenicity. [PDF]

Plants (Basel)
Chu Z, Wang D, Zhang W, Chen J, Yan F, Rao S.   +5 more
europepmc   +2 more sources

Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function. [PDF]

PLoS Genet
Yanagi KS, Chen BJ, Kunjo SO, Topalidou I, Lehrbach N.   +4 more
europepmc   +4 more sources

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin-proteasome system. [PDF]

Clin Transl Med
Wang X, Ma T, Jing Y, Li T, Zhao X, Zhao G, Gao R, Kong L, Chen X.   +8 more
europepmc   +3 more sources

Determination of Expression and Relationships of Nedd4-Related E3 Ubiquitin Ligase-2 (NEDL2) and Ubiquitin Proteasome System Proteins in Developing Rat Pancreatic Tissue. [PDF]

Anat Histol Embryol
Corumluoglu I, Alimogullari E, Sacik U.
europepmc   +3 more sources