Results 11 to 20 of about 17,362,245 (308)

The ubiquitin-proteasome system

Journal of Biosciences, 2006
The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the ...
Nandi, Dipankar, Tahiliani, Pankaj, Kumar, Anujith, Chandu, Dilip   +3 more
core   +5 more sources

Poxvirus Exploitation of the Ubiquitin-Proteasome System

Viruses, 2010
Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been
Alastair Teale, Qian Wang, Kristin Burles, Michele Barry, Kelly Mottet, Nicholas van Buuren   +5 more
doaj   +2 more sources

The ubiquitin-proteasome system and autophagy as guardians of the cellular proteome. [PDF]

FEBS Lett
Dikic I.
europepmc   +2 more sources

The ubiquitin proteasome system and myocardial ischemia

American Journal of Physiology - Heart and Circulatory Physiology, 2013
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic ...
Saul R Powell
exaly   +4 more sources

Ubiquitin-proteasome system regulates pro-crossover protein dynamics during meiosis in Caenorhabditis elegans. [PDF]

PLoS Biol
Zhang H, Liang W, Li M, Yang Y, He L, Nan W, Liu G, Wang B, Hong Y.   +8 more
europepmc   +3 more sources

The Ubiquitin-Proteasome System in Flowering Plant Reproduction: Mechanisms, Functional Diversity, and Regulatory Networks. [PDF]

Plants (Basel)
Jiang X, Su H, Chai M, Yang F, Cai H, Qin Y, Yan M.   +6 more
europepmc   +2 more sources

Ubiquitin-proteasome system regulation of bone remodeling in postmenopausal osteoporosis. [PDF]

Front Cell Dev Biol
Chen X, Zhao T, Zhou H, Zeng Q, Xu H, Dai Y, Yan M.   +6 more
europepmc   +3 more sources

Proteotoxic stress and the ubiquitin proteasome system

Seminars in Cell and Developmental Biology
The ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The efficient elimination is vital for preventing damage to the cell by misfolded proteins, known as proteotoxic stress.
Rachel Kandel, Sonya Neal
exaly   +3 more sources

E2F-mediated activation of mTORC1 through the ubiquitin-proteasome system promotes lung adenocarcinoma progression. [PDF]

Cell Death Dis
Xue W, Wang M, Hu T, Guo S, Hu A, Gu Y, Wang H, Mu G, Zhang W, Fu C, Guo Z, Wei K, Li Y, Wang J.   +13 more
europepmc   +2 more sources

Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma. [PDF]

Int J Genomics
Huo D, Feng Y, Yu Z, Xie W, Jin H.
europepmc   +2 more sources