Results 11 to 20 of about 118,443 (293)
The ubiquitin-proteasome system [PDF]
Journal of Biosciences, 2006 The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the ...
Nandi, Dipankar +3 more
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ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS [PDF]
Сибирский онкологический журнал, 2016 The review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown.
E. V. Ivanova +3 more
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Laboratory Animal Research, 2022 Background Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons.
Ju-Bin Kang +3 more
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The Ubiquitin-Proteasome System in Neurodegeneration [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases.
Chris McKinnon, Sarah J. Tabrizi
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Stressing the ubiquitin-proteasome system [PDF]
Cardiovascular Research, 2009 Unfolded and misfolded proteins are inherently toxic to cells and have to be quickly and efficiently eliminated before they intoxicate the intracellular environment. This is of particular importance during proteotoxic stress when, as a consequence of intrinsic or extrinsic factors, the levels of misfolded proteins are transiently or persistently ...
Nico P, Dantuma, Kristina, Lindsten
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Ubiquitin-proteasome system in diabetic retinopathy [PDF]
PeerJ, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes, being the most prevalent reason for blindness among the working-age population in the developed world.
Zane Svikle +6 more
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The ubiquitin-proteasome system is required for African swine fever replication. [PDF]
PLoS ONE, 2017 Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil +4 more
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Functional analysis of proteasome-associated ubiquitin ligases in plants [PDF]
, 2022 Degradation of intracellular proteins by the ubiquitin-proteasome system (UPS) is a sophisticated mechanism that begins with anchoring ubiquitin molecules to a substrate and ends with proteasome-dependent proteolysis.
Wang, Zhishuo
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Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality. [PDF]
PLoS ONE, 2016 It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity).
Cory W Baumann +2 more
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The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo
Life Science Alliance, 2023 The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro, whereas FAT10 degradation depends on the 26S proteasome in cellulo, shown by impairing 26S function via Rpt2 knockdown.
Franziska Oliveri +4 more
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