Results 41 to 50 of about 118,443 (293)

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

Open Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska   +2 more
doaj   +1 more source

The nuclear ubiquitin-proteasome system [PDF]

Journal of Cell Science, 2006
In eukaryotes, thousands of genes have to be organized and expressed in the cell nucleus. Conformational and kinetic instability of nuclear structure and components appear to enable cells to use the encoded information selectively. The ubiquitin-proteasome system is active in distinct nuclear domains and plays a major role controlling the initial steps
openaire   +2 more sources

Pathophysiological mechanisms of statin‐associated myopathies: possible role of the ubiquitin‐proteasome system

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Statins are the cornerstone of pharmacotherapy for atherosclerotic cardiovascular disease. While these drugs are generally safe, treatment adherence is not optimal in a considerable proportion of patients because of the adverse effects on ...
Amirhossein Sahebkar, Arrigo F.G. Cicero, Paolo Di Giosia, Irene Pomilio, Cosimo Andrea Stamerra, Paolo Giorgini, Claudio Ferri, Stephan vonHaehling, Maciej Banach, Tannaz Jamialahmadi   +9 more
doaj   +1 more source

Viral entry and the ubiquitin‐proteasome system [PDF]

Cellular Microbiology, 2020
Viruses confiscate cellular components of the ubiquitin-proteasome system (UPS) to facilitate many aspects of the infectious cycle. The 26S proteasome is an ATP-dependent, multisubunit proteolytic machine present in all eukaryotic cells. The proteasome executes the controlled degradation of functional proteins, as well as the hydrolysis of aberrantly ...
Seth M. Schneider, Becky H. Lee, Anthony V. Nicola   +2 more
openaire   +2 more sources

The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology. [PDF]

J Asthma Allergy
Shuzhou Deng,1,2 Le Ding,1,3 Yisong Qian,1 Xuan Huang1 1The National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical ...
Deng S, Ding L, Qian Y, Huang X.
europepmc   +3 more sources

The ubiquitin‐proteasome system in Alzheimer's disease [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Biology of the UPS The involvement of the UPS in AD pathogenesis The UPS as a link between Aβ and tau interaction Conclusions AbstractAccumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ...
openaire   +3 more sources

The Role of Ubiquitin-Proteasome System in the Pathogenesis of Severe Acute Respiratory Syndrome Coronavirus-2 Disease

International Journal of Inflammation, 2023
Different protein degradation pathways exist in cells. However, the bulk of cellular proteins are degraded by the ubiquitin-proteasome system (UPS), which is one of these pathways.
Fikadu Seyoum Tola
doaj   +1 more source

Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article [PDF]

, 2023
Petala Matutino Santos,1 Giovanna Pereira Campos,1 Camila Nascimento2 1Center for Mathematics, Computing and Cognition (CMCC), Federal University of ABC (UFABC), São Paulo, Brazil; 2Department of Psychiatry, University of São Paulo Medical School, São ...
Nascimento C, Pereira Campos G, Matutino Santos P   +2 more
core  

Ubiquitin-dependent and -independent proteasomal protein degradation. [PDF]

, 2023
A. UPS protein degradation resulting from (1) ubiquitin system targeting followed by (2) proteasomal protein degradation. B. Proteins with ubiquitin-independent degrons are directly bound and degraded by the proteasome without ubiquitin system targeting.
Frank W. Albert (7879037), Randi Avery (15383490), Mahlon A. Collins (15383487)   +2 more
core   +1 more source

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux

Cell Reports, 2018
Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim, Seoyoung Park, Jung Hoon Lee, Ji Young Mun, Won Hoon Choi, Yejin Yun, Jeeyoung Lee, Ji Hyeon Kim, Min-Ji Kang, Min Jae Lee   +9 more
doaj   +1 more source