RAB40C regulates SNX9 stability <i>via</i> the ubiquitin-proteasome system and modulates the Hippo signaling pathway of prostate adenocarcinoma. [PDF]
Cent Eur J ImmunolQin L +5 more
europepmc +3 more sources
The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]
, 2013 Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core +1 more source
F1000Research, 2015 The ubiquitin-proteasome system is the major degradation pathway for short-lived proteins in eukaryotic cells. Targets of the ubiquitin-proteasome-system are proteins regulating a broad range of cellular processes including cell cycle progression, gene ...
Maisha Chowdhury, Cordula Enenkel
doaj +1 more source
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation
Life Science Alliance, 2022 Inactivation of N-terminal acetyltransferase A is found to alter Rpn4 as well as E3 ligase abundance, causing up-regulation of Ubiquitin–proteasome activity.
Ilia Kats +6 more
doaj +1 more source
The transcription factor ANAC017 links mitochondrial retrograde signaling with the ubiquitin-proteasome system to control mitochondrial function in Arabidopsis. [PDF]
Plant CommunZhao Y +9 more
europepmc +2 more sources
The ubiquitin proteasome system in neuropathology [PDF]
Acta Neuropathologica, 2009 The ubiquitin proteasome system (UPS) orchestrates the turnover of innumerable cellular proteins. In the process of ubiquitination the small protein ubiquitin is attached to a target protein by a peptide bond. The ubiquitinated target protein is subsequently shuttled to a protease complex known as the 26S proteasome and subjected to degradative ...
openaire +2 more sources
Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
core +1 more source
Regulation of SCF Ubiquitin Ligases by Jab1/Csn5 and the Cop9 Signalosome [PDF]
, 2006 SCF ubiquitin ligases regulate the ubiquitin-dependent proteolysis of a myriad of substrate proteins, including p27, Cyclin E, and IkBa. To further gain insight into SCF regulation and function, we purified SCF from mammalian cells and found the Cop9 ...
Cope, Gregory Allan
core +1 more source
The Ubiquitin-Proteasome System: A Key Regulatory Hub in Myocarditis Leading to Dilated Cardiomyopathy. [PDF]
J Inflamm ResXiang Yin, Dongfei Wang, Jialan Lyu, Jie Ding, Zhicheng Pan, Kai Wang, Xiaogang Guo Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Xiaogang Guo ...
Yin X +6 more
europepmc +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Statins are the cornerstone of pharmacotherapy for atherosclerotic cardiovascular disease. While these drugs are generally safe, treatment adherence is not optimal in a considerable proportion of patients because of the adverse effects on ...
Amirhossein Sahebkar +9 more
doaj +1 more source