Editorial: Ubiquitin proteasome system (UPS) and ubiquitin-independent proteasome-mediated proteolysis (UIPP) crosstalk in development and disease. [PDF]
Front Cell Dev BiolSharon M, Stohwasser R.
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The nuclear ubiquitin-proteasome system [PDF]
Journal of Cell Science, 2006 In eukaryotes, thousands of genes have to be organized and expressed in the cell nucleus. Conformational and kinetic instability of nuclear structure and components appear to enable cells to use the encoded information selectively. The ubiquitin-proteasome system is active in distinct nuclear domains and plays a major role controlling the initial steps
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MicroRNAs as the critical regulators of ubiquitin-proteasome system through F-box protein targeting during tumor progression. [PDF]
Cancer Cell IntAkhlaghipour I, Moghbeli M.
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The ubiquitin‐proteasome system in Alzheimer's disease [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Biology of the UPS The involvement of the UPS in AD pathogenesis The UPS as a link between Aβ and tau interaction Conclusions AbstractAccumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ...
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The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]
, 2013 The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A. +12 more
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International Journal of Inflammation, 2023 Different protein degradation pathways exist in cells. However, the bulk of cellular proteins are degraded by the ubiquitin-proteasome system (UPS), which is one of these pathways.
Fikadu Seyoum Tola
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Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux
Cell Reports, 2018 Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim +9 more
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Site-Specific Proteasome Inhibitors
Biomolecules, 2021 Proteasome is a multi-subunit protein degradation machine, which plays a key role in the maintenance of protein homeostasis and, through degradation of regulatory proteins, in the regulation of numerous cell functions. Proteasome inhibitors are essential
Alexei F. Kisselev
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Viral entry and the ubiquitin‐proteasome system [PDF]
Cellular Microbiology, 2020 Viruses confiscate cellular components of the ubiquitin-proteasome system (UPS) to facilitate many aspects of the infectious cycle. The 26S proteasome is an ATP-dependent, multisubunit proteolytic machine present in all eukaryotic cells. The proteasome executes the controlled degradation of functional proteins, as well as the hydrolysis of aberrantly ...
Seth M. Schneider +2 more
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Chemical proteasome inhibition as a novel animal model of inner retinal degeneration in rats.
PLoS ONE, 2019 Chemical proteasome inhibition has been a valuable animal model of neurodegeneration to uncover roles for the ubiquitin-proteasome system in the central nervous system.
Masaaki Kageyama +4 more
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