Results 21 to 30 of about 164,141 (292)

Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats

Journal of Inflammation, 2011
Hypercatabolism is common under septic conditions. Skeletal muscle is the main target organ for hypercatabolism, and this phenomenon is a vital factor in the deterioration of recovery in septic patients.
Gao Tao, Yu Wenkui, Tang Shaoqiu, Li Weiqin, Zhu Weiming, Li Ning, Chen Qiyi, Zhang Juanjuan, Li Jieshou   +8 more
doaj   +1 more source

A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]

, 2015
The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core   +2 more sources

Ubiquitin Proteasome System in Stress and Disease [PDF]

Biochemistry Research International, 2012
The proteasome is an ATP-dependent multisubunit self-compartmentalised protease complex. It is the major regulator of intracellular proteins turnover. The majority of proteins degraded by proteasomes are modified by covalent attachment of polyubiquitin chains.
Dmitry Karpov, Michael H. Glickman, Shoshana Bar-Nun, Philip Coffino   +3 more
doaj   +4 more sources

Proteasome inhibition-enhanced fracture repair is associated with increased mesenchymal progenitor cells in mice.

PLoS ONE, 2022
The ubiquitin/proteasome system controls the stability of Runx2 and JunB, proteins essential for differentiation of mesenchymal progenitor/stem cells (MPCs) to osteoblasts.
Hengwei Zhang, Xing Li, Jiatong Liu, Xi Lin, Lingpeng Pei, Brendan F Boyce, Lianping Xing   +6 more
doaj   +2 more sources

Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain [PDF]

, 2004
To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression by inhibiting cyclin B proteolysis ...
Coffino, Philip, D'Onofrio, Mariapina, Deshaies, Raymond J., Fushman, David, King, Randall W., Peters, Noel R., Sakamoto, Kathleen M., Tochtrop, Gregory P., Varadan, Ranjani, Verma, Rati, Zhang, Mingsheng   +10 more
core   +2 more sources

The Proteasome-Ubiquitin System Is Required for Efficient Killing of Intracellular Streptococcus pneumoniae by Brain Endothelial Cells

mBio, 2014
Streptococcus pneumoniae (pneumococcus) is a Gram-positive bacterium that causes serious invasive diseases, such as pneumonia, bacteremia, and meningitis, with high morbidity and mortality throughout the world.
Federico Iovino, Henrik Gradstedt, Jetta J. Bijlsma   +2 more
doaj   +1 more source

Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition. [PDF]

PLoS ONE, 2010
Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short ...
Esther Gies, Inga Wilde, Jason M Winget, Maria Brack, Barak Rotblat, Carolina Arias Novoa, Aruna D Balgi, Poul H Sorensen, Michel Roberge, Thibault Mayor   +9 more
doaj   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System [PDF]

, 2011
We have generated a set of dual-reporter human cell lines and devised a chase protocol to quantify proteasomal degradation of a ubiquitin fusion degradation (UFD) substrate, a ubiquitin ligase CRL2^(VHL) substrate, and a ubiquitin-independent substrate ...
Aghajan, Alvarez-Castelao, Bence, Beskow, Boyault, Boyault, Cao, Chou, Colson, Dantuma, DeLaBarre, Deshaies, Ding, Eldridge, Elofsson, Finley, Giaever, Golbik, Ito, Janiesch, Ju, Kane, Kimbrel, Lee, Lois, Milhazes, Müller, Nawrocki, Neuber, Noguchi, Ohh, Patel, Rabouille, Raymond J. Deshaies, Richly, Schrader, Soucy, Tsui-Fen Chou, Tsujimoto, Wang, Wang, Weissman, Yamamoto, Yamamoto, Yamamoto, Yang, Ye, Ye, Ye, Zhang, Zhang   +50 more
core   +3 more sources

Role of the Ubiquitin Proteasome System in the Heart [PDF]

Circulation Research, 2013
Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review
J. Pagan, T. Seto, M. Pagano, CITTADINI, ANTONIO   +3 more
openaire   +7 more sources