Targeting the Ubiquitin-Proteasome System in Atrial Fibrillation: Mechanistic Insights and Translational Perspectives. [PDF]
Curr Issues Mol BiolHuang R, Pu Z, Chen Z.
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The ubiquitin-proteasome system is an important driver of EBV-associated nasopharyngeal carcinoma progression: a meta-analysis of transcriptomic data. [PDF]
Sci RepRatnawati H +4 more
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The Ubiquitin-Proteasome System in Neurodegeneration [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases.
Chris McKinnon, Sarah J. Tabrizi
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The emerging role of ubiquitin-proteasome system dysfunction in the pathogenesis of perioperative neurocognitive disorders: a narrative review. [PDF]
Front Behav NeurosciMa M, Yang J, Yang Y, Li L.
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Stressing the ubiquitin-proteasome system [PDF]
Cardiovascular Research, 2009 Unfolded and misfolded proteins are inherently toxic to cells and have to be quickly and efficiently eliminated before they intoxicate the intracellular environment. This is of particular importance during proteotoxic stress when, as a consequence of intrinsic or extrinsic factors, the levels of misfolded proteins are transiently or persistently ...
Nico P, Dantuma, Kristina, Lindsten
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The ubiquitin-proteasome system is required for African swine fever replication. [PDF]
PLoS ONE, 2017 Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil +4 more
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Dual Targeting of IDH2 and the Ubiquitin-Proteasome System Reveals a Functional Vulnerability in Breast Cancer Models. [PDF]
Cancers (Basel)Gharari N +5 more
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Regulation of CHK1 by the Ubiquitin–Proteasome System [PDF]
The FEBS Journal, 2020 The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al. provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to ...
Cartel, Maëlle, Didier, Christine
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Functional analysis of proteasome-associated ubiquitin ligases in plants [PDF]
, 2022 Degradation of intracellular proteins by the ubiquitin-proteasome system (UPS) is a sophisticated mechanism that begins with anchoring ubiquitin molecules to a substrate and ends with proteasome-dependent proteolysis.
Wang, Zhishuo
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Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality. [PDF]
PLoS ONE, 2016 It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity).
Cory W Baumann +2 more
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