Mitochondrial Regulation of the 26S Proteasome [PDF]
Cell Reports, 2020 Summary: The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs.
Jerzy Adamski +2 more
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Cryo-EM structure of the plant 26S proteasome [PDF]
Plant Communications, 2022 Targeted proteolysis is a hallmark of life. It is especially important in long-lived cells that can be found in higher eukaryotes, like plants. This task is mainly fulfilled by the ubiquitin–proteasome system.
Alexander Schleiffer +2 more
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FAT10 and NUB1L cooperate to activate the 26S proteasome [PDF]
Life Science Alliance, 2023 26S proteasome activation is achieved by the collective binding of the ubiquitin-like modifier FAT10 and its interaction partner NUB1L, causing gate opening in a USP14-independent way.
Florian Brockmann +6 more
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Degradation of Intrinsically Disordered Proteins by the NADH 26S Proteasome [PDF]
Biomolecules, 2020 The 26S proteasome is the endpoint of the ubiquitin- and ATP-dependent degradation pathway. Over the years, ATP was regarded as completely essential for 26S proteasome function due to its role in ubiquitin-signaling, substrate unfolding and ensuring its ...
Peter Tsvetkov +3 more
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Substrate-interacting pore loops of two ATPase subunits determine the degradation efficiency of the 26S proteasome [PDF]
Nature CommunicationsThe 26S proteasome is the major eukaryotic protease responsible for the degradation of misfolded, damaged, and obsolete regulatory proteins. Commitment to degradation occurs when conserved pore loops in the heterohexameric ATPase motor of the proteasome ...
Erika López-Alfonzo +7 more
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20S and 26S proteasome-binding proteins of the rabbit brain: A proteomic dataset [PDF]
Data in Brief, 2021 Fractions of 26S and 20S proteasomes isolated from the rabbit brain by the method of salt fractionation (salt-induced precipitation) contain intrinsic proteasome proteins responsible for assembly of the core particle and regulatory particle of proteasome
Olga Buneeva +4 more
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A kinetic model for USP14 regulated substrate degradation in 26S proteasome. [PDF]
PLoS Computational BiologyDespite high-resolution structural studies on the USP14-proteasome-substrate complexes, time-resolved cryo-electron microscopy (cryo-EM) results on USP14-regulated allostery of the 26S proteasome are still very limited and a quantitative understanding of
Di Wu +3 more
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Research and Therapeutic Advances of 26S Proteasome Subunit in Non-small Cell Lung Cancer [PDF]
Chinese Journal of Lung CancerLung cancer is one of the most common cancers worldwide and is the leading cause of cancer deaths. Lung adenocarcinoma is the most common type of lung cancer.
Chenrui MOU +4 more
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SnRK2.6-mediated phosphorylation stabilizes proteasome regulator 1 (PTRE1) to enhance 26S proteasome activity and coordinate ABA signaling in Arabidopsis [PDF]
Plant CommunicationsAbscisic acid (ABA) regulates diverse aspects of plant growth, particularly adaptive responses to abiotic stress. Although the ubiquitin–proteasome system is recognized as a pivotal pathway for degrading key components of ABA signaling, the mechanisms ...
Peng-Chao Hao +3 more
doaj +2 more sources
Mechanisms and regulation of substrate degradation by the 26S proteasome [PDF]
Nature Reviews Molecular Cell BiologyChristine Gee +2 more
exaly +2 more sources