The 26S Proteasome and Initiation of Gene Transcription [PDF]
Biomolecules, 2014 Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control.
Geetha Durairaj, Peter Kaiser
doaj +5 more sources
Mechanisms and regulation of substrate degradation by the 26S proteasome [PDF]
Nature Reviews Molecular Cell BiologyChristine Gee +2 more
exaly +2 more sources
The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo
Life Science Alliance, 2023 The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro, whereas FAT10 degradation depends on the 26S proteasome in cellulo, shown by impairing 26S function via Rpt2 knockdown.
Franziska Oliveri +4 more
doaj +1 more source
Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT). [PDF]
PLoS ONE, 2012 26S proteasome is a macromolecular multi-subunit complex responsible for recognizing, unfolding, and ultimately destroying proteins. It remains poorly understood how 26S proteasome activity is regulated.
Jian Xu +3 more
doaj +1 more source
Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. [PDF]
PLoS ONE, 2012 Oxidative stress is believed to cause endothelial dysfunction, an early event and a hallmark in cardiovascular diseases (CVD) including hypertension, diabetes, and dyslipidemia.
Jian Xu +5 more
doaj +1 more source
The Hunt for Degrons of the 26S Proteasome [PDF]
Biomolecules, 2019 Since the discovery of ubiquitin conjugation as a cellular mechanism that triggers proteasomal degradation, the mode of substrate recognition by the ubiquitin-ligation system has been the holy grail of research in the field. This entails the discovery of recognition determinants within protein substrates, which are part of a degron, and explicit E3 ...
Hadar Ella, Yuval Reiss, Tommer Ravid
openaire +3 more sources
PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes. [PDF]
PLoS ONE, 2014 Accumulation of aggregation-prone human alpha 1 antitrypsin mutant Z (AT-Z) protein in PiZ mouse liver stimulates features of liver injury typical of human alpha 1 antitrypsin type ZZ deficiency, an autosomal recessive genetic disorder.
Christopher J Haddock +7 more
doaj +1 more source
Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster [PDF]
, 2004 The intracellular localization of the 26S proteasome in the different ovarian cell types of Drosophila melanogaster was studied by means of immunofluorescence staining and laser scanning microscopy, with the use of antibodies specific for regulatory ...
Andó, István +5 more
core +1 more source
Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor [PDF]
, 2012 Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth.
Caroline R. Wilkinson (117644) +47 more
core +2 more sources
PLoS ONE, 2014 The 26S proteasome plays a fundamental role in almost all eukaryotic cells, including vascular endothelial cells. However, it remains largely unknown how proteasome functionality is regulated in the vasculature.
Hongtao Liu +3 more
doaj +1 more source