Results 21 to 30 of about 27,758 (248)
Dss1 Is a 26S Proteasome Ubiquitin Receptor [PDF]
Molecular Cell, 2014 The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome. The proteasome subunits Rpn10 and Rpn13 are known to bind ubiquitin, but genetic and biochemical data suggest the existence of at least one ...
Paraskevopoulos, Konstantinos +11 more
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Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. [PDF]
PLoS ONE, 2015 The PAF complex (PAFc) participates in various steps of the transcriptional process, from initiation to termination, by interacting with and recruiting various proteins to the proper locus for each step. PAFc is an evolutionarily conserved, multi-protein
Hwa-Young Sun +3 more
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Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis
Biomolecules, 2023 The 26S proteasome is the largest and most complicated protease known, and changes to proteasome assembly or function contribute to numerous human diseases.
Daniel Betancourt +2 more
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Regulation of repair by the 26S proteasome [PDF]
BioMed Research International, 2002 Cellular processes such as transcription and DNA repair may be regulated through diverse mechanisms, including RNA synthesis, protein synthesis, posttranslational modification and protein degradation. The 26S proteasome, which is responsible for degrading a broad spectrum of proteins, has been shown to interact with several nucleotide excision repair ...
Sweder, K., Madura, K.
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Frontiers in Chemistry, 2018 The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome.
Geeta Rao +6 more
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Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain. [PDF]
PLoS ONE, 2013 Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging.
Carolin Giannini +7 more
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Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution.
PLoS ONE, 2015 Insulin-Degrading-Enzyme (IDE) is a Zn2+-dependent peptidase highly conserved throughout evolution and ubiquitously distributed in mammalian tissues wherein it displays a prevalent cytosolic localization.
Diego Sbardella +9 more
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Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly
Redox Biology, 2018 Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized ...
Martín Hugo +7 more
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Food & Nutrition Research, 2016 Background: Type I interferons (IFN-α/β) have broad and potent immunoregulatory and antiproliferative activities. However, it is still known whether the dietary flavonoids exhibit their antiviral and anticancer properties by modulating the function of ...
Sheng Li +7 more
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Molecular and cellular dynamics of the 26S proteasome
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021 In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome is a 2.5 MDa multisubunit complex comprising the 20S core particle, where degradation is executed, and one or two regulatory particles which prepare substrates for degradation.
Sakata, Eri +2 more
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