Results 191 to 200 of about 11,341 (256)

Inducing TRIB2-targeted protein degradation to reverse chemoresistance in acute myeloid leukaemia. [PDF]

Biochem J
Rigby E, Fasanella Masci F, Narayanan A, Kania E, Harris JA, Williams J, Zhang B, Liu L, Richmond L, Zhou F, Ding K, Carmody RJ, Eyers PA, Keeshan K.   +13 more
europepmc   +1 more source

Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction [PDF]

, 2020
Ding, Xunshan, Iyer, Rugmani, Klein, Samuel, Metzger, Daniel, Novotny, Christopher, Smith, Gordon I., Swaminath, Gayathri, Talukdar, Saswata, Yoshino, Jun, Yoshino, Mihoko, Zhou, Heather H., Zhou, Yingjiang   +11 more
core   +1 more source

Tumor microenvironment-activated ferritin nanovector enables enhanced tumor delivery of KRAS^G12C inhibitors and degraders. [PDF]

Front Cell Dev Biol
Abbinantefina AP, Tito C, Masciarelli S, Tisci G, Sortoluzzi S, Ceci P, Falvo E, Exertier C, Troilo F, Petrozza V, Mai A, Rotili D, Fazi F, Colotti G.   +13 more
europepmc   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design. [PDF]

ChemMedChem
Nikovia K, Kapsalis M, Georgoulakis M, Panousis A, Neochoritis CG.   +4 more
europepmc   +1 more source

Multifunctional specificity of the protein C/activated protein C Gla domain [PDF]

, 2017
Ajzner, Éva, Dahlbäck, Björn, Dua, Sonia, Karageorgi, Stalo, Lane, David A., Preston, Roger J. S., Razzari, Cristina   +6 more
core  

Discovery of a First-in-Class Murine Double Minute 2-Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor Activity. [PDF]

MedComm (2020)
Guan X, Xie L, Guo H, Ma L, Zhou J, Luo L, Yang H, Wu Y, Liu J, Wang Y, Huang X, Liu J, Zhang Y, Chen W, Chen Y, Xu L, Han X.   +16 more
europepmc   +1 more source

PROTAC-based protein degradation: a window of opportunity for melanoma therapy. [PDF]

J Biomed Sci
Gentile G, D'Aguanno S, Di Martile M, Petricca A, Valentini E, Scalera S, Del Bufalo D.   +6 more
europepmc   +1 more source

Computational Modeling of PROTAC Ternary Complexes as Ensembles Using SILCS-xTAC. [PDF]

J Chem Inf Model
Nordquist EB, Zhao M, Yu W, MacKerell AD.   +3 more
europepmc   +1 more source

Proteolysis Targeting Chimera Loaded Extracellular Vesicles for Developing Triple Negative Breast Cancer Treatment. [PDF]

J Extracell Vesicles
Erwin N, De U, Xiao Y, Wang L, Maharjan CK, Pan X, Zuo D, Awasthee N, Zheng G, Liao D, Zhang W, He M.   +11 more
europepmc   +1 more source

Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors. [PDF]

ACS Med Chem Lett
Le Manach C, Viklund J, Kwapień K, Winiwarter S.   +3 more
europepmc   +1 more source