Results 171 to 180 of about 11,341 (256)

PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington's Disease. [PDF]

J Am Chem Soc
Lu PC, Huang YA, Wali N, Tseng MC, He RY, Chern Y, Wei TT, Shie JJ, Huang JJ.   +8 more
europepmc   +1 more source

A machine learning-based pharmacokinetics predictor (EGFR-PROPK) for EGFR-targeting PROTACs. [PDF]

Commun Chem
Zhang R, Li F, Liu Y, Geng Y, Zhou Y, Zeng L, Bai F.   +6 more
europepmc   +1 more source

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability. [PDF]

JACS Au
Murakami Y, Ishida S, Cho N, Yuki H, Ohta M, Honma T, Demizu Y, Terayama K.   +7 more
europepmc   +1 more source

Prospects and advances of PROTAC in the treatment of hematologic malignancies. [PDF]

Exp Hematol Oncol
Wang X, Zhang M, Mei H.
europepmc   +1 more source

Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications. [PDF]

ACS Pharmacol Transl Sci
Knoll N, Neamati N, Üren A.
europepmc   +1 more source

PROTAC-mediated multi-target protein degradation in Alzheimer's disease: mechanistic insights, therapeutic applications, and translational challenges. [PDF]

RSC Med Chem
Wang B, Li Y, Yao T, Shen X, Li H, Jiang W, Li X, Zhu Z.   +7 more
europepmc   +1 more source

PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells. [PDF]

Cells
Kim Y, Kim JW, Choi J, Kim J, Park S, Choi W, An H, Kim J, Kim M, Choi S, Lim J, Lee HI, Lee S.   +12 more
europepmc   +1 more source

AI-Based Prediction of PROTAC- and Molecular Glue-Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz-2. [PDF]

Arch Pharm (Weinheim)
Riepenhausen L, Sarnow AC, Robaa D, Sippl W.   +3 more
europepmc   +1 more source

Targeting BCL-xL in Myeloid Malignancies: From Inhibitors to PROTAC. [PDF]

J Cell Mol Med
Cilloni D, Ferrando A, Frassoni F.
europepmc   +1 more source

Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry. [PDF]

Chem Sci
Gadallah MI, Nonhof KL, Nayak D, Zhang P, Dioli O, Zheng G, Olsen SK, Zhou D, Brodbelt JS.   +8 more
europepmc   +1 more source