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Progress in the controllability technology of PROTAC
European Journal of Medicinal ChemistryProteolysis-targeting chimaera (PROTAC) technology functions by directly targeting proteins and catalysing their degradation through an event-driven mode of action, a novel mechanism with significant clinical application prospects for various diseases.
Xin He, Zhibing Weng, Yi Zou
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Efficient PROTAC-ing: combinational use of PROTACs with signaling pathway inhibitors
Trends in Biochemical SciencesTargeted protein degradation is an innovative therapeutic modality for the degradation of disease-causing proteins. In a recent report combining high-throughput screening of small-molecule compounds and biochemical analyses, Mori et al. identified certain inhibitors of cellular pathways, such as PARylation and proteostatic pathways, which enhance ...
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The state of the art of PROTAC technologies for drug discovery
European Journal of Medicinal Chemistry, 2022Zhen-ming Liu, Ping Xu
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PROTAC targeted protein degraders: the past is prologue
Nature Reviews Drug Discovery, 2022Miklos Bekes +2 more
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Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer
Angewandte Chemie - International Edition, 2021Guoqiang Dong, Chunquan Sheng
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