Results 121 to 130 of about 14,786 (290)

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design, Development and Therapy
YiLin Luo, Xin Yue Bai, Lei Zhang, Qian Qian Hu, Ning Zhang, Jun Zhi Cheng, Ming Zheng Hou, Xiao Long Liu Yan ‘an Small Molecule Innovative Drug R&D Engineering Research Center, School of Medicine, Yan’an University, Yan’an, People’s Republic of ...
Luo Y, Bai XY, Zhang L, Hu QQ, Zhang N, Cheng JZ, Hou MZ, Liu XL   +7 more
doaj  

Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron [PDF]

, 2010
Background Tools for in vivo manipulation of protein abundance or activity are highly beneficial for life science research. Protein stability can be efficiently controlled by conditional degrons, which induce target protein degradation at ...
Marc Jungbluth, Christian Renicke, Christof Taxis   +2 more
core   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands [PDF]

, 2018
Thioamide substitution influences hydrogen bond and n→π* interactions involved in the conformational stability of protein secondary structures and oligopeptides.
Alemán, Alessio Ciulli, Bartlett, Bartlett, Bondeson, Buckley, Buckley, Bürgi, Chan, Choudhary, Choudhary, Choudhary, Culik, Engel-Andreasen, Frost, Gadd, Galdeano, Hon, Lee, Maniaci, Min, Miwa, Mukherjee, Newberry, Pedro Soares, Platts, Rahim, Reiner, Seebach, Soares, Tran, Van Molle, Walters, Wiberg, Xavier Lucas, Zengerle   +35 more
core   +2 more sources

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Modulation of microtubule acetylation by the interplay of TPPP/p25, SIRT2 and new anticancer agents with anti-SIRT2 potency [PDF]

, 2017
The microtubule network exerts multifarious functions controlled by its decoration with various proteins and post-translational modifications. The disordered microtubule associated Tubulin Polymerization Promoting Protein (TPPP/p25) and the NAD ...
Adél Szabó, Attila Lehotzky, Judit Oláh, Judit Ovádi, Manfred Jung, Marianna Csaplár, Matthias Schiedel, Péter Lőw, Sándor Szunyogh, Tibor Szénási   +9 more
core   +2 more sources

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression [PDF]

, 2019
Dependence on the 26S proteasome is an Achilles' heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to drug-resistant disease relapse and ...
Banerjee, Sourav, Chapman, Owen, Chavez, Lukas, Cooper, Kimberly L., Costello, Caitlin, de la Vega, Laureano, Dixon, Jack E., Gutierrez, Haydee L., Juarez, Edwin F., Lee, Jenna J., Lei, Xiaoguang, Liang, Ruqi, Mayfield, Joshua E., Mesirov, Jill P., Sah, Robert L., Tandon, Vasudha, Wang, Jue, Wei, Tiantian, Wiley, Sandra E., Xiao, Junyu   +19 more
core   +3 more sources