Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy [PDF]
Nature Communications, 2021 Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects.
Chi Zhang +7 more
doaj +7 more sources
Chemotherapy‐Enabled Colorectal Cancer Immunotherapy of Self‐Delivery Nano‐PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance [PDF]
Advanced ScienceThe chemo‐regulation abilities of chemotherapeutic medications are appealing to address the low immunogenicity, immunosuppressive lactate microenvironment, and adaptive immune resistance of colorectal cancer.
Lin‐Ping Zhao +7 more
doaj +6 more sources
Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy [PDF]
International Journal of NanomedicineYue Song,1,* Qing-Qing Dong,2,* Yi-Ke Ni,3 Xiao-Ling Xu,3 Chao-Xiang Chen,3 Wei Chen2 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310003, People’s Republic of China; 2ICU ...
Song Y +5 more
doaj +7 more sources
Nano-PROTACs for precision medicine: engineering strategies for enhanced targeting and potency [PDF]
Journal of NanobiotechnologyProteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic modality that leverages the endogenous ubiquitin-proteasome system (UPS) to achieve targeted protein degradation.
Xiaoping Yang +9 more
doaj +5 more sources
Recent Advances in Nanomedicine: Cutting-Edge Research on Nano-PROTAC Delivery Systems for Cancer Therapy [PDF]
PharmaceuticsProteolysis-targeting chimeras (PROTACs) selectively degrade target proteins by recruiting intracellular E3 ubiquitin ligases, overcoming the limitations of traditional small-molecule inhibitors that merely block protein function.
Xiaoqing Wu +7 more
doaj +6 more sources
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy [PDF]
Signal Transduction and Targeted TherapyPROteolysis TArgeting Chimeras (PROTACs) have been considered the next blockbuster therapies. However, due to their inherent limitations, the efficacy of PROTACs is frequently impaired by limited tissue penetration and particularly insufficient cellular ...
Liuqing Yang +12 more
doaj +5 more sources
The Role of Reactive Oxygen Species in Lung Cancer Development: Nanomedicine as a Therapeutic Strategy [PDF]
BiomoleculesLung cancer remains a leading cause of mortality worldwide, driven by increased tobacco use, industrialization, and air pollution. Despite advancements in diagnostics and treatments, effective therapies are still lacking.
Manuel Olazábal-Morán +3 more
doaj +3 more sources
Angewandte Chemie - International Edition, 2022 Protease inhibitors can modulate intratumoral metabolic processes to reprogram the immunosuppressive tumor microenvironment (TME), which however suffer from the limited efficacy and off-targeted side effects.
Chi Zhang, Shasha He, Kanyi Pu
exaly +5 more sources
Nano Letters, 2023 Therapy-induced DNA damage is the most common strategy to inhibit tumor cell proliferation, but the therapeutic efficacy is limited by DNA repair machinery.
Hong Cheng, Shi-Ying Li
exaly +4 more sources
In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance [PDF]
Signal Transduction and Targeted TherapyCastration-resistant prostate cancer demonstrates intrinsic or acquired resistance to second-generation androgen-targeted therapies, posing a challenge in clinical treatment.
Fei-Ya Yang +13 more
doaj +4 more sources