Results 31 to 40 of about 841 (115)

표적형 항암 치료를 위한 리소좀 특이적 나노약물 [PDF]

, 2023
학위논문(박사) -- 서울대학교대학원 : 공과대학 재료공학부, 2023. 2. 안철희.Despite the development of cancer therapy, conventional chemodrugs are still mainly used for cancer treatment due to its wide range of application and accessibility.
조한희
core  

Development of PROTAC Degrader Drugs for Cancer [PDF]

The development of novel drug modalities is necessary to overcome the current critical issues in the treatment of cancer, namely toxicity, insufficient efficacy, and the development of resistance.
Ciulli, Alessio, O'Connor, Suzanne, Vetma, Vesna   +2 more
core   +3 more sources

Magnetically navigated nano-PROTAC ameliorates acute lung injury

Journal of Nanobiotechnology
Acute lung injury (ALI) is an acute inflammatory lung disease with high rates of morbidity and mortality. The lack of efficient pharmacological treatments for ALI resulted in poor outcomes and prognosis.Poly(lactic-co-glycolic acid) (PLGA) was used to carry magnetic nanoparticles and TRIM24-targeted PROTAC (dTRIM24), which was further camouflaged with ...
Chen, Sheng, Chen, Enen, Su, Jianfen, Gong, Yingjie, Tang, Shiqi, Qin, Aiping, Shen, Ao, Tang, Shunqing, Zhang, Lingmin   +8 more
openaire   +3 more sources

Application of PROTACs in target identification and validation [PDF]

Proteolysis targeting chimeras (PROTACs), as a novel therapeutic drug model, has received widespread attention from academia and the pharmaceutical industry.
Hua Li, Jing Liang, Lixia Chen, Rui Zhu, Wenyi Wei, Yali Wang, Yang Liu, Yueying Yang   +7 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

PROTAC: a revolutionary technology propelling small molecule drugs into the next golden age [PDF]

Proteolysis Targeting Chimera (PROTAC) is a heterobifunctional molecule comprising three core components: a target protein ligand (typically a small-molecule inhibitor), a linker, and an E3 ubiquitin ligase ligand.
Chen Chen, Chen Chen, Haibo Sun, Haibo Sun, Jiale Cai, Jiale Cai, Jiayue Wang, Jiayue Wang, Qunshan Zhu, Xinmeng Zhang, Xinmeng Zhang, Yuqiu Cui, Yuqiu Cui   +12 more
core   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Targeting RNA-binding proteins with small molecules: perspectives and challenges [PDF]

RNA-binding proteins (RBPs) play critical roles in numerous biological processes because they regulate RNA function by directly interacting with RNA molecules.
Olivier Mpungi Konde, Tania Bishola Tshitenge, Tania Bishola Tshitenge, Tania Bishola Tshitenge, Williams Balela Balela   +4 more
core   +1 more source