New-generation advanced PROTACs as potential therapeutic agents in cancer therapy
Molecular CancerProteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, representing a burgeoning therapeutic approach with the potential to address pathogenic proteins that have historically posed challenges for ...
Chao Wang +4 more
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The E3 ubiquitin ligases regulate PD-1/PD-L1 protein levels in tumor microenvironment to improve immunotherapy [PDF]
, 2023 The tumor microenvironment (TME) is the tumor surrounding environment, which is critical for tumor development and progression. TME is also involved in clinical intervention and treatment outcomes.
Bo Hou +5 more
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Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation [PDF]
, 2022 Contains fulltext : 283270.pdf (Publisher’s version ) (Open ...
Abdelmohsen, Loai K.E.A. +8 more
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Drug Carriers: A Review on the Most Used Mathematical Models for Drug Release [PDF]
, 2022 Carriers are protective transporters of drugs to target cells, facilitating therapy under each points of view, such as fast healing, reducing infective phenomena, and curing illnesses while avoiding side effects.
Trucillo, Paolo
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Targeted Degradation of eEF2K by a Structure-Guided PROTAC Strategy for the Treatment of Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Cao S +10 more
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Nanoparticles-based phototherapy systems for cancer treatment : Current status and clinical potential [PDF]
, 2022 Remarkable progress in phototherapy has been made in recent decades, due to its non-invasiveness and instant therapeutic efficacy. In addition, with the rapid development of nanoscience and nanotechnology, phototherapy systems based on nanoparticles or ...
Fontana, Flavia +6 more
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Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery. [PDF]
MedComm (2020)Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Zhao M +6 more
europepmc +2 more sources
Versatile Nano‐PROTAC‐Induced Epigenetic Reader Degradation for Efficient Lung Cancer Therapy
Advanced Science, 2022 AbstractRecent evidence has indicated that overexpression of the epigenetic reader bromodomain‐containing protein 4 (BRD4) contributes to a poor prognosis of lung cancers, and the suppression of its expression promotes cell apoptosis and leads to tumor shrinkage.
Huan‐Tian Zhang +10 more
openaire +3 more sources
Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery. [PDF]
ChemMedChemCrude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Hübner AF, Barthels F.
europepmc +2 more sources
Targeted Protein Degradation Tools: Overview and Future Perspectives
Biology, 2020 Targeted protein inactivation (TPI) is an elegant approach to investigate protein function and its role in the cellular landscape, overcoming limitations of genetic perturbation strategies.
Yuri Prozzillo +6 more
doaj +1 more source