Results 261 to 270 of about 14,786 (290)

Design and optimization strategies of PROTACs and its Application, Comparisons to other targeted protein degradation for multiple oncology therapies.

Bioorganic chemistry (Print)
Recent years have witnessed notable breakthroughs in the field of biotherapeutics. Proteolysis Targeting Chimeras (PROTACs) are novel molecules which used to degrade particular proteins despite the blockage by small drug molecules, which leads to a ...
M. Malarvannan, Sujith Unnikrishnan, S.Monohar, V. Ravichandiran, David Paul   +4 more
semanticscholar   +1 more source

Progress in the controllability technology of PROTAC

European Journal of Medicinal Chemistry
Proteolysis-targeting chimaera (PROTAC) technology functions by directly targeting proteins and catalysing their degradation through an event-driven mode of action, a novel mechanism with significant clinical application prospects for various diseases.
Xin He, Zhibing Weng, Yi Zou
openaire   +2 more sources

Efficient PROTAC-ing: combinational use of PROTACs with signaling pathway inhibitors

Trends in Biochemical Sciences
Targeted protein degradation is an innovative therapeutic modality for the degradation of disease-causing proteins. In a recent report combining high-throughput screening of small-molecule compounds and biochemical analyses, Mori et al. identified certain inhibitors of cellular pathways, such as PARylation and proteostatic pathways, which enhance ...
openaire   +2 more sources

Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC).

Journal of Medicinal Chemistry
Proteolysis-targeting chimeras (PROTACs) selectively eliminate detrimental proteins by exploiting the ubiquitin-proteasome system (UPS), representing a promising therapeutic strategy against various diseases.
Jianchao Zhang, Xiao Chen, Congli Chen, Fengming Li, Xiaoxiao Song, Chaowei Liu, Kefan Liao, Ming-Yuan Su, Chris Soon Heng Tan, Lijing Fang, Hai Rao   +10 more
semanticscholar   +1 more source

Progress of proteolysis-targeting chimeras (PROTACs) delivery system in tumor treatment.

International Journal of Biological Macromolecules
Proteolysis targeting chimeras (PROTACs) can use the intrinsic protein degradation system in cells to degrade pathogenic target proteins, and are currently a revolutionary frontier of development strategy for tumor treatment with small molecules. However,
Lianlian Fan, Weifang Tong, Anhui Wei, X. Mu   +3 more
semanticscholar   +1 more source

PROTACs as Therapeutic Modalities for Drug Discovery in Castration-Resistant Prostate Cancer.

Annual Review of Pharmacology and Toxicology
Castration-resistant prostate cancer (CRPC) presents significant challenges in clinical management due to its resistance to conventional androgen receptor (AR)-targeting therapies. The advent of proteolysis targeting chimeras (PROTACs) has revolutionized
Ling-Yu Wang, Chiu‐Lien Hung, Tsan-Chun Wang, Hung-Chih Hsu, Hsing-Jien Kung, Kwang-huei Lin   +5 more
semanticscholar   +1 more source

PROTACs for prostate cancer

Nature Reviews Urology, 2023
openaire   +2 more sources

Research progress of PROTACs for neurodegenerative diseases therapy.

Bioorganic chemistry (Print)
Neurodegenerative diseases (NDD) are characterized by the gradual deterioration of neuronal function and integrity, resulting in an overall decline in brain function.
Zhifang Cai, Zunhua Yang, Huilan Li, Yuanying Fang   +3 more
semanticscholar   +1 more source

Computational methods and key considerations for in silico design of proteolysis targeting chimera (PROTACs).

International Journal of Biological Macromolecules
Proteolysis-targeting chimeras (PROTACs), as heterobifunctional molecules, have garnered significant attention for their ability to target previously undruggable proteins.
Amr Abbas, Fei Ye
semanticscholar   +1 more source

Developing bacterial PROTACs

Nature Reviews Drug Discovery, 2022
openaire   +2 more sources