Results 41 to 50 of about 1,598,143 (384)
Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]
, 2016 Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P +7 more
core +2 more sources
Inhibition of SARS-CoV 3CL protease by flavonoids
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required.
S. Jo, Suwon Kim, D. Shin, Mi‐Sun Kim
semanticscholar +1 more source
The conserved metalloprotease invadolysin is present in invertebrate haemolymph and vertebrate blood
Biology Open, 2019 We identified invadolysin, a novel essential metalloprotease, for functions in chromosome structure, cell proliferation and migration. Invadolysin also plays an important metabolic role in insulin signalling and is the only protease known to localise to ...
Kanishk Abhinav +6 more
doaj +1 more source
Viscometric Measurement of Protease Activities on Gelatine Substrate
Applied Rheology, 2014 The knowledge of enzymatic activity is necessary in many industrial processes. The common measurement techniques are time-consuming and therefore cost-intensive. Measurements of viscosities are a promising approach as a fast and cheap testing method. The
Sellerberg Monika +4 more
doaj +1 more source
Screening of Proteolytic Enzymes of Streptomyces sp. Local Strain and Their Characterization
Microbiology Indonesia, 2010 Protease of two Streptomyces sp. strain were chosen for characterization because of the large clear zone surrounding the colony in nutrient agar media containing 1% (w/v) skim milk.
DERI YURATMOKO +2 more
doaj +1 more source
Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. [PDF]
, 2018 Mechanisms that sense and regulate epithelial morphogenesis, integrity, and homeostasis are incompletely understood. Protease-activated receptor 2 (Par2), the Par2-activating membrane-tethered protease matriptase, and its inhibitor, hepatocyte activator ...
Balouch, Eaman +8 more
core +1 more source
Proteases as therapeutics [PDF]
Biochemical Journal, 2011 Proteases are an expanding class of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease therapies, and a number of next generation or completely new proteases are in clinical development. Although they are a well-recognized class of targets for inhibitors, proteases themselves have not typically been ...
Michael J. Page +2 more
openaire +3 more sources
Poultry Science, 2021 The effect of supplementation of different enzymatic associations in the feed of broiler chickens formulated with corn dried at 80°C or 110°C on growth performance and carcass yield was evaluated.
Franciele C.N. Giacobbo +7 more
doaj
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
eLife, 2020 Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane seals and pinches off behind the parasite through an unknown mechanism, enclosing the parasite within ...
Christine R Collins +6 more
doaj +1 more source
Related Endogenous Retrovirus-K Elements Harbor Distinct Protease Active Site Motifs
Frontiers in Microbiology, 2018 Background: Endogenous retrovirus-K is a group of related genomic elements descending from retroviral infections in human ancestors. HML2 is the clade of these viruses which contains the most intact provirus copies.
Matthew G. Turnbull +2 more
doaj +1 more source