Citrus psorosis virus movement protein contains an aspartic protease required for autocleavage and the formation of tubule-like structures at plasmodesmata [PDF]
, 2018 Plant virus cell-to-cell movement is an essential step in viral infections. This process is facilitated by specific virus-encoded movement proteins (MPs), which manipulate the cell wall channels between neighboring cells known as plasmodesmata (PD ...
Borniego, María Belén +4 more
core +3 more sources
AKTIVITAS TRIPSIN-LIKE DAN KIMOTRIPSIN-LIKE PADA IKAN SIDAT TROPIK Anguilla bicolor McClelland
Scripta Biologica, 2018 The ability of eel (Anguilla bicolor McClelland) to digest feed protein is highly dependent on the alkaline proteases in the intestine which are trypsin-like and chymotrypsin-like.
Annisa Fitri Larassagita +2 more
doaj +1 more source
Amino acid frequency and domain features serve well for random forest based classification of thermophilic and mesophilic protein; a case study on serine proteases [PDF]
arXiv, 2021 Thermostability is an important prerequisite for enzymes employed for industrial applications. Several machine learning based models have thus been formulated for protein classification based on this particular trait. These models have employed features derived from sequences, structures or both resulting in a >93% accuracy based on a 10-fold cross ...
arxiv
In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway [PDF]
Nature Communications 2016; 7: 13689, 2016 HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the formation of mature infectious particles. There are two competing models for the process of forming the mature HIV-1 core: the disassembly and de novo reassembly model and the non-diffusional ...
arxiv +1 more source
Protein processing characterized by a gel-free proteomics approach [PDF]
, 2008 We describe a method for the specific isolation of representative N-terminal peptides of proteins and their proteolytic fragments. Their isolation is based on a gel-free, peptidecentric proteomics approach using the principle of diagonal chromatography ...
A. Staes +17 more
core +1 more source
Frontiers in Chemistry, 2018 Nwat-MMGBSA is a variant of MM-PB/GBSA based on the inclusion of a number of explicit water molecules that are the closest to the ligand in each frame of a molecular dynamics trajectory.
Irene Maffucci +3 more
doaj +1 more source
Carica papaya Leaf Extract Inhibits SARS-CoV-2 Main Proteases but not Human TMPRSS2: An In-vitro and In-silico Study [PDF]
arXiv, 2022 Carica papaya (CP) leaf is long known for its traditional pharmacological effects against dengue virus and malaria. Therefore, CP could also be a potential solution for the treatment of other infectious diseases, such as coronavirus. In this study, we evaluate the potential effect of the ethanolic CP leaf extract in inhibiting the enzymatic activity of
arxiv
Fractional-order susceptible-infected model: definition and applications to the study of COVID-19 main protease [PDF]
, 2020 We propose a model for the transmission of perturbations across the amino acids of a protein represented as an interaction network. The dynamics consists of a Susceptible-Infected (SI) model based on the Caputo fractional-order derivative. We find an upper bound to the analytical solution of this model which represents the worse-case scenario on the ...
arxiv +1 more source
Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. [PDF]
, 2018 Mechanisms that sense and regulate epithelial morphogenesis, integrity, and homeostasis are incompletely understood. Protease-activated receptor 2 (Par2), the Par2-activating membrane-tethered protease matriptase, and its inhibitor, hepatocyte activator ...
Balouch, Eaman +8 more
core +1 more source
Proteases, Protease-Activated Receptors, and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 Coagulation activation by the TF (tissue factor) pathway plays pivotal roles in triggering platelets and precipitating acute coronary syndromes. Although dual antiplatelet therapy is effective in secondary cardiovascular prevention, combining platelet antagonism with low-dose aspirin and the oral coagulation FXa antagonist rivaroxaban has a synergistic
openaire +3 more sources