Results 281 to 290 of about 695,446 (323)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Acquired HIV-1 drug resistance to reverse transcriptase and protease inhibitors among people failing antiretroviral therapy in Cameroon and implications for future treatment options. [PDF]

AIDS Res Ther
Fokam J, Anim-Keng TT, Pokam BT, Chenwi CA, Ka'e AC, Semengue ENJ, Beloumou Angong OEG, Takou D, Nka AD, Djupsa S, Etame NK, Molimbou E, Ajeh R, Bissek AZ, Colizzi V, Perno CF, Halle-Ekane GE, Ndembi N, Ndjolo A.   +18 more
europepmc   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

Advanced Healthcare Materials, EarlyView.
An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim, Seokheon Hong, Jae Hwi Lee, Jongmin Lee, Jae Jun Kang, Jiseon Bae, Jino Kim, Dong‐Hwee Kim, Jin Yoo, Mi Sun Cha, Su Hee Kim, Youngmee Jung   +11 more
wiley   +1 more source

Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors. [PDF]

Front Immunol
Wang J, Li J, Zhou L, Hou H, Zhang K.
europepmc   +1 more source

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors. [PDF]

J Virol
Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, Song Y, Estes MK, Palzkill T, Prasad BVV.   +9 more
europepmc   +1 more source

Discovery of benzyl carbamate inhibitors of coronavirus M^pro enzymes from a legacy collection of cysteine protease inhibitors

Serafim, Mateus Sá Magalhães, Kronenberger, Thales, Francisco, Karol R., de Sousa Reis, Erik Vinicius, de Oliveira, Ellen Gonçalves, Marcelino e Oliveira, Fernanda Kelly, Fortes, Isadora Serraglio, Fernandes, Thaís Helena Maciel, da Silva, Elany Barbosa, Fajtova, Pavla, Skinner, Danielle E., Syed, Rafay O., de Siqueira-Neto, Jair Lage, Poso, Antti, Mota, Bruno Eduardo Fernandes, Coelho-dos-Reis, Jordana Grazziela Alves, Abrahão, Jônatas Santos, Maltarollo, Vinícius Gonçalves, O’Donoghue, Anthony J., Caffrey, Conor R.   +19 more
openalex   +1 more source

Corrigendum to "Serine protease inhibitors could be of benefit in the treatment of COVID-19 disease". [PDF]

Ther Adv Infect Dis
europepmc   +1 more source

Design and Evaluation of Andrographolide Analogues as SARS-CoV-2 Main Protease Inhibitors: Molecular Modeling and in vitro Studies. [PDF]

Drug Des Devel Ther
Suriya U, Intamalee P, Saeeng R, Wilasluck P, Deetanya P, Wangkanont K, Kanjanasirirat P, Wongwitayasombat C, Nutho B.   +8 more
europepmc   +1 more source

Design, Synthesis,and Biological Evaluation of NovelCore Scaffold-Modified HIV‑1 Protease Inhibitors for OvercomingDrug Resistance

Huiyu Zhou (535329), Yu Gao (69071), Qingqing Yang (1628146), Qi Shan (10516950), Sihan Meng (14507207), Ling Ma (107282), Biao Dong (519216), Juxian Wang (2039833), Guoning Zhang (7417700), Minghua Wang (37199), Shan Cen (107285), Yucheng Wang (154813), Yongsheng Che (131901), Mei Zhu (224674)   +13 more
openalex   +1 more source