Results 191 to 200 of about 331,217 (249)

Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease

, 2011
Weiling Niu, Zhiwei Chen, Prafull S. Gandhi, Austin Vogt, Nicola Pozzi, Leslie A. Pelc, F. Zapata, Enrico Di   +7 more
openalex   +2 more sources

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation. [PDF]

NPJ Parkinsons Dis
Vekrellis K, Lamprokostopoulou A, Melachroinou K, Kokoli M, Zingkou E, Skarveli M, Kolianou A, Samiotaki M, Sotiropoulou G.   +8 more
europepmc   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Host cell and viral protease targets of human SERPINs identified by in silico docking. [PDF]

EMBO J
Rodriguez Galvan J, de Vries M, Belblidia S, Fisher A, Prescott RA, Crosse KM, Hearing P, Mangel WF, Duerr R, Dittmann M.   +9 more
europepmc   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Mitochondrial proteases and their roles in mitophagy in plants, animals, and yeast. [PDF]

Plant Cell Physiol
Ludwig K, Heidorn-Czarna M.
europepmc   +1 more source

Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection

Advanced Functional Materials, EarlyView.
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao, Anna Hu, Elnaz Bavel, Chien‐Hsun Yu, Sixuan Zhang, Vera Maria Kissling, Zhihao Li, Thomas Fintan Moriaty, Katharina Maniura‐Weber, Qun Ren   +9 more
wiley   +1 more source

Emerging Allergens: How Proallergenic Activity Disrupts Epithelial Barriers [Letter]. [PDF]

J Inflamm Res
Wei Y, Xie Z.
europepmc   +1 more source

Isolation, production and characterization of protease from Bacillus Sp isolated from soil sample [PDF]

, 2017
F Soundra Josephine, V. Ramya, Neelam Devi, Suresh Babu Ganapa, Siddalingeshwara K. G, N. B. R. K. Venugopal, T. M. Vishwanatha   +6 more
openalex