Results 121 to 130 of about 355,945 (323)

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Ubiquitin Signaling: Extreme Conservation as a Source of Diversity

Cells, 2014
Around 2 × 103–2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same ...
Alice Zuin, Marta Isasa, Bernat Crosas
doaj   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Control of DNA Replication Initiation by Ubiquitin

Cells, 2018
Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by ...
Esperanza Hernández-Carralero, Elisa Cabrera, Ignacio Alonso-de Vega, Santiago Hernández-Pérez, Veronique A. J. Smits, Raimundo Freire   +5 more
doaj   +1 more source

Activation of STAT3 and its impacts on Proteasome Inhibitor-Induced Apoptosis in Laryngeal Sqaumous Carcinoma [PDF]

, 2017
Qi Song, Xiaoming Li, Huiping Zhang, Qingjia Sun, Lifeng Jia, Lihong Pi, Xiuying Lu, Li, D Parkin, F Bray, J Ferlay, P Pisani, R Leeman, V Lui, J Grandis, S Chen, D Murphy, W Lassoued, G Thurston, M Feldman, J Grandis, S Drenning, A Chakraborty, M Zhou, Q Zeng, C Guo, G Yang, K Khun, X Kong, D Levy, S Kim, O Kwon, Y Hong, J Kim, F Solca, A Snchez, P Nagy, S Thorgeirsson, J Turkson, R Jove, J Bonner, H Trummell, C Willey, B Plants, K Raisch, T Ara, R Nakata, M Sheard, H Shimada, R Buettner, X Li, H Wang, Lu Di, B, X Li, H Wang, Lu Di, B, P Mttnen, K Gehring, J Bergeron, D Thomas, R Orlowski, S Uddin, M Ahmed, P Bavi, C Mitsiades, D Mcmillin, V Kotoula, R Jones, Q Chen, P Voorhees, K Young, N Bruey-Sedano, B Li, Q Dou, P Lara, R Bold, P Mack, A Davies, P Gumerlock, D Gandara, C Li, R Li, J Grandis, Johnson De, D Mcconkey, K Zhu, D Fels, J Ye, A Segan, R Orlowski, D Kuhn, C Li, Y Zang, M Sen, R Leeman-Neill, D Man, Q Wang, Z He   +99 more
openalex   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Supplementary Figure 1 from Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4

, 2023
Xie Yan, Dennis W. Wolff, Taotao Wei, Bo Wang, Caishu Deng, Joseph K. Kirui, Haihong Jiang, Jianbing Qin, Peter W. Abel, Yaping Tu   +9 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Inhibition of Proteasome Activity Induces Concerted Expression of Proteasome Genes and de Novo Formation of Mammalian Proteasomes [PDF]

, 2003
Silke Meiners, Dirk Heyken, Andrea Weller, Antje Ludwig, Karl Stangl, Peter‐M. Kloetzel, Elke Krüger   +6 more
openalex   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source