Results 131 to 140 of about 411,261 (379)

Mutant dominant-negative rhodopsin∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking

Frontiers in Molecular Biosciences
Dominant mutations in the rhodopsin gene (Rho) contribute to 25% of autosomal dominant retinitis pigmentosa (adRP), characterized by photoreceptor loss and progressive blindness. One such mutation, Rho∆I256, carries a 3-bp deletion, resulting in the loss
Bowen Cao, Bowen Cao, Johanna Valentina Dahlen, Merve Sen, Merve Sen, Tina Beyer, Tobias Leonhard, Ellen Kilger, Blanca Arango-Gonzalez, Marius Ueffing   +9 more
doaj   +1 more source

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

eLife, 2019
Defective mismatch repair leads to increased mutation rates, and germline loss-of-function variants in the repair component MLH1 cause the hereditary cancer predisposition disorder known as Lynch syndrome. Early diagnosis is important, but complicated by
Amanda B Abildgaard, Amelie Stein, Sofie V Nielsen, Katrine Schultz-Knudsen, Elena Papaleo, Amruta Shrikhande, Eva R Hoffmann, Inge Bernstein, Anne-Marie Gerdes, Masanobu Takahashi, Chikashi Ishioka, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen   +12 more
doaj   +1 more source

Cell cycle specific radiosensitisation by the disulfiram and copper complex [PDF]

, 2017
The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of the effect of
Anselmi, Giorgio, Bell, Caitlin, Mairs, Robert, Tesson, Mathias   +3 more
core   +1 more source

Bioinspired Design of a Wet‐Adhesive Cornea Glue Based on Recombinant Human Protein Networks

Advanced Functional Materials, EarlyView.
Natures protein‐based high performance materials e.g. elastin, silk and muscle proteins have been mimicked by a new protein‐hybrid material based on redesigned human partial sequences only, showing high wet‐adhesiveness and elasticity for biomedical applications.
Anna Resch, Matthias C. Huber, Alexander Resch, Andreas Schreiber, Thabo Lapp, Jan Dittrich, Frederic Eisen, Austin Julian Michalec, Viktoria Planz, Adrianna Kolberg, Mathaeus Tschaikowsky, Daniel Böhringer, Maike Windbergs, Thomas Reinhard, Bernd Rolauffs, Bizan N. Balzer, Günther Schlunck, Stefan M. Schiller   +17 more
wiley   +1 more source

Exploring the Interactome of the Queuine Salvage Protein DUF2419 in Entamoeba histolytica

Cells
Entamoeba histolytica causes amebiasis, a significant global health issue, with millions affected annually, especially in developing countries. EhDUF2419, an important protein involved in E.
Jun Ye, Meirav Trebicz-Geffen, Serge Ankri   +2 more
doaj   +1 more source

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Front. Cell Dev. Biol., 2019
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis.
Chunyan Li, Xin Wang, Xuezhi Li, Kaixin Qiu, Fengjuan Jiao, Yidan Liu, Q. Kong, Yan Liu, Yili Wu   +8 more
semanticscholar   +1 more source

The First Review on Nano‐Agricultural Applications of MXene and MBene‐Based Materials for Plant‐Immunoengineering, Controlled Protection, and Inducing Biostimulation Mechanisms

Advanced Materials, EarlyView.
MXene and MBene nanomaterials show significant potential in addressing critical challenges in biomedicine, applied biology, agriculture, and the environment. From a nano‐agricultural perspective, this relatively young field has witnessed emerging advances towards applications for plant‐immunoengineering, biostimulation, and controlled delivery ...
Alireza Rafieerad, Ahmad Amiri, Maik Böhmer, Soofia Khanahmadi   +3 more
wiley   +1 more source

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition

eLife, 2016
The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a prerequisite for substrate processing and is accomplished ...
Corey M Dambacher, Evan J Worden, Mark A Herzik Jr., Andreas Martin, Gabriel C Lander   +4 more
doaj   +1 more source

Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors [PDF]

, 2020
Richard J. Jones, Ramesh Singh, Fazal Shirazi, Jie Wan, Hua Wang, Xiaobin Wang, Min Jin Ha, Muhamed Baljević, Isere Kuiatse, R. Eric Davis, Robert Z. Orlowski   +10 more
openalex   +1 more source

A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns [PDF]

, 2010
Petal development and senescence entails a normally irreversible process. It starts with petal expansion and pigment production, and ends with nutrient remobilization and ultimately cell death.
Aharoni, Andersen, Andersson, Basset, Breeze, Brian Thomas, Buchanan-Wollaston, Buchanan-Wollaston, Carol Wagstaff, Chanasut, Channelière, Courtney, Doi, Dudareva, Elizabeth Harrison, Emily Breeze, Eulgem, Fang, Faragher, Ferrante, Fujita, Gibbings, Gombert, Guo, Hall, Hilary Rogers, Hoeberichts, Holton, Hong, Hsiao, Huang, Irene Bramke, Jung, Khodakovskaya, Langston, Le Page-Degivry, Lee, Leverentz, Lim, Lin, Meyer, Mizoguchi, Moyle, Munne-Bosch, Nakashima, Oono, Oono, Panavas, Price, Primack, Rabbani, Ranwala, Ranwala, Reddy, Reid, Roberts, Roca, Rogers, Ross, Rudnicki, Sarah Thornber, Shinozaki, Singh, Takahashi, Tony Stead, van der Krol, van Doorn, van Doorn, Vicky Buchanan-Wollaston, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Weaver, Zhu   +75 more
core   +2 more sources