Results 211 to 220 of about 195,005 (265)
The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors. [PDF]
Int J Mol SciPyndiah S.
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Editorial: Ubiquitin proteasome system (UPS) and ubiquitin-independent proteasome-mediated proteolysis (UIPP) crosstalk in development and disease. [PDF]
Front Cell Dev BiolSharon M, Stohwasser R.
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Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation. [PDF]
Protein CellWang H +10 more
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The proteostasis network is a therapeutic target in acute myeloid leukemia.
BloodLam K +17 more
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Annual Review of Biophysics and Biomolecular Structure, 1999
▪ Abstract  Proteasomes are large multisubunit proteases that are found in the cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their ubiquitous presence and high abundance in these compartments reflects their central role in cellular protein turnover.
M, Bochtler +4 more
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▪ Abstract  Proteasomes are large multisubunit proteases that are found in the cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their ubiquitous presence and high abundance in these compartments reflects their central role in cellular protein turnover.
M, Bochtler +4 more
openaire +2 more sources
Current Opinion in Structural Biology, 1997
The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery.
Baumeister, W., Lupas, A.
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The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery.
Baumeister, W., Lupas, A.
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Seminars in Oncology, 2004
The proteasome is an abundant multicatalytic enzyme complex present in the cytoplasm and nucleus of all eukaryotic cells. The primary function of the proteasome is to degrade proteins. While it was once thought to act primarily as a cellular "garbage disposal" that removed damaged or misfolded proteins from cells, the proteasome is now known to also ...
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The proteasome is an abundant multicatalytic enzyme complex present in the cytoplasm and nucleus of all eukaryotic cells. The primary function of the proteasome is to degrade proteins. While it was once thought to act primarily as a cellular "garbage disposal" that removed damaged or misfolded proteins from cells, the proteasome is now known to also ...
openaire +4 more sources