Results 231 to 240 of about 253,705 (262)

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling. [PDF]

Transl Lung Cancer Res
Deng S, Li Z, Liu N, Wang Y, Sun J, Guan B, Du J.   +6 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

PA200 modulates immunoproteasome structure and activity. [PDF]

Nat Commun
Živković D, Bosc-Rosati A, Dafun AS, Mourtada F, Grygier P, Yazgili AS, Jansma M, Rawski M, Czarna A, Bohn S, Zak KM, Santos Dias Mourão A, Reiling N, Zemke L, Guo K, Behr J, Burlet-Schiltz O, Popowicz GM, Marcoux J, Meiners S, Bousquet MP.   +20 more
europepmc   +1 more source

Thermodynamic Preference Between Deprotonation Pathways in Boronic Acid-Based Proteasome Inhibitors: Insights from a DFT Study. [PDF]

Pharmaceuticals (Basel)
Toshev N, Dimitrov I, Muradyan O, Delchev V, Dudev T.   +4 more
europepmc   +1 more source

Preserved anabolic skeletal muscle capacity in response to exercise and protein intake after critical illness. [PDF]

Crit Care
Fischer-Hammerschmied A, Tardif N, Mandić M, Gustafsson T, Apro W, Helleberg J, Amouzandeh M, Grip J, Seldén D, Rooyackers O, Sundström Rehal M.   +10 more
europepmc   +1 more source

Stimulating proteasomal degradation in human proteinopathies. [PDF]

FEBS J
Gierisch ME, Barchi E, Dantuma NP.
europepmc   +1 more source

Paraptosis, a new type of cell death that can be applied to cancer treatment. [PDF]

Front Oncol
Wang X, Ma J, Tan B, Wang Y, Wang Z, Hou C, Chen Q, Jin X.   +7 more
europepmc   +1 more source

Molecular glue mediated degradation of cannabinoid receptor 1 for cancer therapy. [PDF]

NPJ Drug Discov
Kashkush A, Tadesse K, Insler B, Benhamou RI.   +3 more
europepmc   +1 more source