Results 231 to 240 of about 195,005 (265)
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Molecular Aspects of Medicine, 2009
Rising interest in the mechanism and function of the proteasomes and the ubiquitin system revealed that it is hard to find any aspect of the cellular metabolic network that is not directly or indirectly affected by the degradation system. This includes the cell cycle, the "quality control" of newly synthesized proteins (ERAD), transcription factor ...
Tobias, Jung +2 more
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Rising interest in the mechanism and function of the proteasomes and the ubiquitin system revealed that it is hard to find any aspect of the cellular metabolic network that is not directly or indirectly affected by the degradation system. This includes the cell cycle, the "quality control" of newly synthesized proteins (ERAD), transcription factor ...
Tobias, Jung +2 more
openaire +2 more sources
Proteasomes and proteasome inhibition in the central nervous system
Free Radical Biology and Medicine, 2001Although the proteasome is responsible for the majority of intracellular protein degradation, and has been demonstrated to play a pivotal role in a diverse array of cellular activities, the role of the proteasome in the central nervous system is only beginning to be elucidated.
Q, Ding, J N, Keller
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Anti‐20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28
Arthritis & Rheumatism, 2006AbstractObjectiveThe ubiquitin‐proteasome system plays a central role in cellular homeostasis as well as in regulation of the inflammatory and stress responses. However, the occurrence of autoantibodies against 20S proteasome has, to date, been considered to be a nonspecific epiphenomenon in patients with autoimmune disorders. This study was undertaken
Michael, Brychcy +6 more
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2012
In May 2003, the US Food and Drug Administration (FDA) granted accelerated approval for the use of the first-in-class proteasome inhibitor bortezomib as a third-line therapy in multiple myeloma, and the European Union followed suit a year later. Bortezomib has subsequently been approved for multiple myeloma as a second-line treatment on its own and as ...
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In May 2003, the US Food and Drug Administration (FDA) granted accelerated approval for the use of the first-in-class proteasome inhibitor bortezomib as a third-line therapy in multiple myeloma, and the European Union followed suit a year later. Bortezomib has subsequently been approved for multiple myeloma as a second-line treatment on its own and as ...
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Current Protocols in Immunology, 2015
AbstractProteasome inhibitors are indispensable research tools in immunology and cell biology. With numerous proteasome inhibitors available commercially, choosing the appropriate compound for a biological experiment may be challenging, especially for a novice. This unit provides an overview of the proteasome inhibitors commonly used in research.
Downey, S.L. +3 more
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AbstractProteasome inhibitors are indispensable research tools in immunology and cell biology. With numerous proteasome inhibitors available commercially, choosing the appropriate compound for a biological experiment may be challenging, especially for a novice. This unit provides an overview of the proteasome inhibitors commonly used in research.
Downey, S.L. +3 more
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2002
The field of intracellular proteolysis has received increasing attention over the last decade. This is due in large part to the fact that, beyond its classical functions that have been acknowledged for a long time, such as destruction of abnormal proteins or cleavage of precursor polypeptides, it was realized during the 1990s that intracellular ...
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The field of intracellular proteolysis has received increasing attention over the last decade. This is due in large part to the fact that, beyond its classical functions that have been acknowledged for a long time, such as destruction of abnormal proteins or cleavage of precursor polypeptides, it was realized during the 1990s that intracellular ...
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2012
The ubiquitin-proteasomal system is an essential element of the protein quality control machinery in cells. The central part of this system is the 20S proteasome. The proteasome is a barrel-shaped multienzyme complex, containing several active centers hidden at the inner surface of the hollow cylinder.
Tobias, Jung, Tilman, Grune
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The ubiquitin-proteasomal system is an essential element of the protein quality control machinery in cells. The central part of this system is the 20S proteasome. The proteasome is a barrel-shaped multienzyme complex, containing several active centers hidden at the inner surface of the hollow cylinder.
Tobias, Jung, Tilman, Grune
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2012
Cancer is one of the most frightful diseases mostly resulting in mortality; it has recently become more possible to overcome with the help of new therapies. In this direction, carcinogenesis is defined as a complicated process that can include several different factors that contribute to its progress. Proteasome is implicated in cancer studies as it is
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Cancer is one of the most frightful diseases mostly resulting in mortality; it has recently become more possible to overcome with the help of new therapies. In this direction, carcinogenesis is defined as a complicated process that can include several different factors that contribute to its progress. Proteasome is implicated in cancer studies as it is
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2005
The proteasome is a highly complex, ATP-dependent protease, consisting of over 30 subunits, and dedicated mainly to the degradation of ubiquitin-protein conjugates. Proteasomes are evolutionarily conserved in the eukaryotic kingdom, and those of yeast are well suited to serve as a general model.
David S, Leggett +2 more
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The proteasome is a highly complex, ATP-dependent protease, consisting of over 30 subunits, and dedicated mainly to the degradation of ubiquitin-protein conjugates. Proteasomes are evolutionarily conserved in the eukaryotic kingdom, and those of yeast are well suited to serve as a general model.
David S, Leggett +2 more
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USP14-regulated allostery of the human proteasome by time-resolved cryo-EM
Nature, 2022Shuwen Zhang, Daniel Finley, Zhaolong Wu
exaly