Results 111 to 120 of about 1,016,262 (299)
, 2008 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core
Discovery of a Potent, Selective, and Orally Active Proteasome Inhibitor for the Treatment of Cancer
, 2016 The ubiquitin−proteasome pathway plays a central role in regulation of the production and destruction of cellular proteins. These pathways mediate proliferation and cell survival, particularly in malignant cells.
Ambrogio Oliva (2452111) +17 more
core +1 more source
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
, 2014 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core
Proteostat aggresome staining of A549 cells treated with proteasome inhibitor or DMSO as a control.
Proteostat aggresome staining of A549 cells treated with proteasome inhibitor or DMSO as a control.
Mahak Sharma (4543984) +8 more
core +1 more source
The persisting challenge of selective and specific proteasome inhibition
, 2009 Since the discovery of the proteasome and its structure elucidation intensive research programs in academic institutions and pharmaceutical industries led to identification of a wide spectrum of synthetic and natural small proteasomal inhibitors ...
Michael Groll +5 more
core +1 more source
Use of carfilzomib in second-line therapy and beyond for relapsed multiple myeloma
Blood and Lymphatic Cancer: Targets and Therapy, 2017 Divaya Bhutani, Jeffrey A Zonder Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA Abstract: The development of proteasome inhibitors has been a major advance in therapy of multiple myeloma, accounting, in ...
Bhutani D, Zonder JA
doaj
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
, 2011 A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.
Howard Hughes Medical Institute (HHMI)
core
Advanced Science, EarlyView.In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang +18 more
wiley +1 more source