Results 131 to 140 of about 3,106,146 (396)

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity [PDF]

, 1999
Gunter Schmidtke, Hermann−Georg Holzhütter, Matthew Bogyo, Norman Kairies, M. Groll, Rita de Giuli, Sabine Emch, Marcus Groettrup   +7 more
openalex   +1 more source

Cystargolide-based amide and ester Pz analogues as proteasome inhibitors and anti-cancer agents

, 2022
Carlos Viera, Bradley T. Stevens, Talysa Viera, Cameron Zielinski, Lee A. Uranga, Snezna Rogelj, Praveen Patidar, Rodolfo Tello‐Aburto   +7 more
openalex   +1 more source

Proteasome Inhibitors Reduce Thrombospondin-1 Release in Human Dysferlin-Deficient Myotubes [PDF]

, 2020
Esther Fernández‐Simón, Cinta Lleixà, Xavier Suárez‐Calvet, Jordi Díaz‐Manera, Isabel Illa, Eduard Gallardo, Noemí de Luna   +6 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Activation of STAT3 and its impacts on Proteasome Inhibitor-Induced Apoptosis in Laryngeal Sqaumous Carcinoma [PDF]

, 2017
Qi Song, Xiaoming Li, Huiping Zhang, Qingjia Sun, Lifeng Jia, Lihong Pi, Xiuying Lu, Li, D Parkin, F Bray, J Ferlay, P Pisani, R Leeman, V Lui, J Grandis, S Chen, D Murphy, W Lassoued, G Thurston, M Feldman, J Grandis, S Drenning, A Chakraborty, M Zhou, Q Zeng, C Guo, G Yang, K Khun, X Kong, D Levy, S Kim, O Kwon, Y Hong, J Kim, F Solca, A Snchez, P Nagy, S Thorgeirsson, J Turkson, R Jove, J Bonner, H Trummell, C Willey, B Plants, K Raisch, T Ara, R Nakata, M Sheard, H Shimada, R Buettner, X Li, H Wang, Lu Di, B, X Li, H Wang, Lu Di, B, P Mttnen, K Gehring, J Bergeron, D Thomas, R Orlowski, S Uddin, M Ahmed, P Bavi, C Mitsiades, D Mcmillin, V Kotoula, R Jones, Q Chen, P Voorhees, K Young, N Bruey-Sedano, B Li, Q Dou, P Lara, R Bold, P Mack, A Davies, P Gumerlock, D Gandara, C Li, R Li, J Grandis, Johnson De, D Mcconkey, K Zhu, D Fels, J Ye, A Segan, R Orlowski, D Kuhn, C Li, Y Zang, M Sen, R Leeman-Neill, D Man, Q Wang, Z He   +99 more
openalex   +1 more source

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Haematologica, 2012
Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
S. Ling, Edwin Lau, A. Al-shabeeb, A. Nikolic, A. Catalano, H. Iland, N. Horvath, P. Ho, S. Harrison, S. Harrison, S. Fleming, D. Joshua, D. Joshua, J. Allen   +13 more
semanticscholar   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

Cell Reports, 2012
The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim, Won Jae Lee, Youngdoo Kim, Jong Wook Chang, Sungmin Song, Yong-Keun Jung   +5 more
doaj   +1 more source

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors [PDF]

, 2008
Deborah J. Kuhn, Sally A. Hunsucker, Qing Chen, Peter M. Voorhees, Marian Orłowski, Robert Z. Orlowski   +5 more
openalex   +1 more source

Supplementary Figures 1 - 4 from <i>BRAF</i> V600E Is a Determinant of Sensitivity to Proteasome Inhibitors

, 2023
Davide Zecchin, Valentina Boscaro, Enzo Médico, Ludovic Barault, Miriam Martini, Sabrina Arena, Carlotta Cancelliere, Alice Bartolini, Emily Crowley, Alberto Bardelli, Margherita Gallicchio, Federica Di Nicolantonio   +11 more
openalex   +2 more sources