Results 201 to 210 of about 3,106,146 (396)

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies

, 2018
Meng Lei, Huayun Feng, Enhe Bai, Hui Zhou, Jia Wang, Jingmiao Shi, Xueyuan Wang, Shihe Hu, Zhaogang Liu, Yongqiang Zhu   +9 more
openalex   +1 more source

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Nature Chemical Biology, 2017
Jing Li, Tanya Yakushi, F. Parlati, A. Mackinnon, Christian Perez, Yuyong Ma, K. Carter, Sharon Colayco, Gavin K. Magnuson, Brock T Brown, Kevin H. Nguyen, S. Vasile, E. Suyama, Layton H Smith, E. Sergienko, A. Pinkerton, T. Chung, A. Palmer, I. Pass, S. Hess, Seth M. Cohen, R. Deshaies   +21 more
semanticscholar   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Optimization of species-selective reversible proteasome inhibitors for the treatment of malaria [PDF]

Suraksha Gahalawat, S. Ray, Xiaoyu Zhang, Xiaoyi Deng, Yan Han, Aloysus K. Lawong, David M. Shackleford, Kasiram Katneni, Gong Chen, Peng Li, Alice Ng, Long‐Jin Zhong, Meiyu Hu, Mitchell P. McInerney, Wen Wang, Jessica Saunders, Daniel Collins, Jaya Jayaseelan, Cassandra L. Noack, Bikash C. Maity, Nirupam De, Benoı̂t Laleu, Simon F. Campbell, Margaret A. Phillips, Susan A. Charman, Joseph M. Ready   +25 more
openalex   +1 more source

Anthracyclines attenuate Nrf1-dependent proteolytic pathways and potentiate proteasome inhibitor cytotoxicity. [PDF]

Mol Biol Cell
Vangala JR, Ward MA, Albalawi B, Elshazly AM, Hosseini N, Shen S, Byers HA, Carter C, Liu J, Radhakrishnan SK.   +9 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Depletion of IgG-producing plasma cells in the colon by treatment of proteasome inhibitor ameliorates chronic DSS-induced colitis in mice. [PDF]

Sci Rep
Ebihara S, Kimoto Y, Katsumoto R, Konishi N.   +3 more
europepmc   +1 more source

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Journal of Medicinal Chemistry, 2017
Christian Perez, Jing Li, F. Parlati, Matthieu Rouffet, Yuyong Ma, A. Mackinnon, T. Chou, R. Deshaies, Seth M. Cohen   +8 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines

, 2015
Kyle A. Totaro, Dominik Barthelme, Peter T. Simpson, Robert T. Sauer, Jason K. Sello   +4 more
openalex   +2 more sources