Results 221 to 230 of about 1,016,262 (299)

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

Thrombocytopenia With High C-reactive Protein in Myeloma Patients Treated With Proteasome Inhibitor and/or Immunomodulatory Drugs. [PDF]

Cancer Diagn Progn
Suzuki K, Gunji T, Kawashima M, Uryu H, Nagao R, Saito T, Nishiwaki K, Yano S.   +7 more
europepmc   +1 more source

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF‐κB Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin‐like proteins mediating protein degradation, has not been fully elucidated in CAC ...
Yuqi Han, Yaru Xia, Weiquan Li, Jiaming Wu, Tiexi Yu, Diaoyi Tan, Daojia Miao, Wen Li, Xuejiao Dong, Jiemin Li, Yu Jiao, Guixiao Huang, Xiaoping Zhang, Hongmei Yang   +13 more
wiley   +1 more source

Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed/refractory multiple myeloma. [PDF]

Haematologica
Bishop RT, Li T, Sudalagunta P, Nasr M, Nyman KJ, Alugubelli RR, Meads M, Frieling J, Nerlakanti N, Tauro M, Fang B, Grant S, Koomen J, Silva AS, Shain KH, Lynch CC.   +15 more
europepmc   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes. [PDF]

Biochemistry
Wang J, Kjellgren A, DeMartino GN.
europepmc   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells. [PDF]

Pharmaceuticals (Basel)
Kusaczuk M, Tyszka N, Krętowski R, Cechowska-Pasko M.   +3 more
europepmc   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Phase I study of TQB3602, an oral proteasome inhibitor, in relapsed and refractory multiple myeloma. [PDF]

Cancer Med
Tang W, Li Y, Zhang L, Zhong X, Liang Q, Zheng Y, Liu Y, Wang Y, Wang X, Zeng Y, Fang B, Zheng L, Niu T.   +12 more
europepmc   +1 more source