Results 11 to 20 of about 107,280 (285)
Microbial proteasomes as drug targets.
PLoS Pathogens, 2021 Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms.
Hao Zhang, Gang Lin
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Molecules, 2022 Proteasome inhibitors have shown relevant clinical activity in several hematological malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient outcomes such as survival and quality of life, when compared with other therapies ...
Carlota Leonardo-Sousa +7 more
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Postnatal proteasome inhibition induces neurodegeneration and cognitive deficiencies in adult mice: a new model of neurodevelopment syndrome. [PDF]
PLoS ONE, 2011 Defects in the ubiquitin-proteasome system have been related to aging and the development of neurodegenerative disease, although the effects of deficient proteasome activity during early postnatal development are poorly understood.
Rocío Romero-Granados +3 more
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Blood Cancer Journal, 2020 Protein homeostasis is critical for maintaining eukaryotic cell function as well as responses to intrinsic and extrinsic stress. The proteasome is a major portion of the proteolytic machinery in mammalian cells and plays an important role in protein ...
Yanyan Gu +9 more
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Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. [PDF]
PLoS ONE, 2014 The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracellular
Sayani Dasgupta +6 more
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Paradoxical inhibition of cellular protein expression by proteasome inhibitors
Biomolecular Concepts, 2012 Proteasome inhibitors are used as anticancer drugs, however, the precise mechanisms of their selective activity against cancer cells are not understood well.
Gartel Andrei L.
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BMC Cancer, 2012 Background The ubiquitin-proteasome system and macroautophagy (hereafter referred to autophagy) are two complementary pathways for protein degradation. Emerging evidence suggests that proteasome inhibition might be a promising approach for tumor therapy.
Liu Chuan +8 more
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Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition
Scientific Reports, 2023 Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1 and the impact of proteasome inhibition on hepatic function ...
Sébastien Soubeyrand +2 more
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Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. [PDF]
PLoS ONE, 2008 Proteasome activity is an important part of viral replication. In this study, we examined the effect of proteasome inhibitors on the replication of vesicular stomatitis virus (VSV) and poliovirus.
Nickolay Neznanov +6 more
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