BMC Cancer, 2012 Background The ubiquitin-proteasome system and macroautophagy (hereafter referred to autophagy) are two complementary pathways for protein degradation. Emerging evidence suggests that proteasome inhibition might be a promising approach for tumor therapy.
Liu Chuan +8 more
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Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition
Scientific Reports, 2023 Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1 and the impact of proteasome inhibition on hepatic function ...
Sébastien Soubeyrand +2 more
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Haematologica, 2013 The ex vivo sensitivity of pediatric leukemia cells to the proteasome inhibitor bortezomib was compared to 3 next generation proteasome inhibitors: the epoxyketone-based irreversible proteasome inhibitors carfilzomib, its orally bio-available analog ONX ...
Denise Niewerth +13 more
doaj +1 more source
Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. [PDF]
PLoS ONE, 2008 Proteasome activity is an important part of viral replication. In this study, we examined the effect of proteasome inhibitors on the replication of vesicular stomatitis virus (VSV) and poliovirus.
Nickolay Neznanov +6 more
doaj +1 more source
The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors
Data in Brief, 2015 We recently developed a new assay to measure proteasome activity in vitro (CAPA for capture proteasome assay) [1], based on proteasome capture on an antibody-coated plate.
Nathalie Vigneron +2 more
doaj +1 more source
Proteasome inhibitors in glioblastoma
Oncology Letters, 2017 Glioblastomas (GBM) are the tumors originating from the star shaped supportive cells in brain known as astrocytes. These tumors are highly cancerous as they have the ability to proliferate very quickly. New therapeutic strategies are being developed worldwide to fight against deadly GBM, which has median survival time of just 14 months.
Huang, Wen-Juan +2 more
openaire +4 more sources
Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding. [PDF]
PLoS ONE, 2013 The proteasome is a proteolytic machinery that executes the degradation of polyubiquitinated proteins to maintain cellular homeostasis. Proteasome inhibition is a unique and effective way to kill cancer cells because they are sensitive to proteotoxic ...
Jiro Kikuchi +11 more
doaj +1 more source
Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer
Molecular & Cellular Oncology, 2017 The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors.
Kamil Lisek +2 more
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Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview
Molecules, 2016 Proteasome emerged as an important target in recent pharmacological research due to its pivotal role in degrading proteins in the cytoplasm and nucleus of eukaryotic cells, regulating a wide variety of cellular pathways, including cell growth and ...
Romina A. Guedes +3 more
doaj +1 more source
Different degree in proteasome malfunction has various effects on root growth possibly through preventing cell division and promoting autophagic vacuolization. [PDF]
PLoS ONE, 2012 The ubiquitin/proteasome pathway plays a vital role in plant development. But the effects of proteasome malfunction on root growth, and the mechanism underlying this involvement remains unclear.
Xianyong Sheng +5 more
doaj +1 more source