Results 91 to 100 of about 373,630 (305)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Understanding the interactions among local communities, protected areas and tourism: case studies of Kruger National Park and Purnululu National Park

, 2010
New management approaches for protected areas emphasise a 'humans in nature' perspective, with protected areas seen as intrinsically connected with surrounding human populations. Tourism often provides a connection between these communities and protected
Strickland-Munro, Jennifer. K.
core  

Melatonin increases the chilling tolerance of chloroplast in cucumber seedlings by regulating photosynthetic electron flux and the ascorbate-glutathione cycle

Frontiers in Plant Science, 2016
The aim of the study was to monitor the effects of exogenous melatonin on cucumber (Cucumis sativus L.) chloroplasts and explore the mechanisms through which it mitigates chilling stress. Under chilling stress, chloroplast structure was seriously damaged
Hailiang Zhao, Hailiang Zhao, Hailiang Zhao, Lin Ye, Lin Ye, Lin Ye, Lin Ye, Yuping Wang, Xiaoting Zhou, Xiaoting Zhou, Xiaoting Zhou, Junwei Yang, Junwei Yang, Junwei Yang, Jiawei Wang, Jiawei Wang, Jiawei Wang, Kai Cao, Kai Cao, Kai Cao, Zhirong Zou, Zhirong Zou, Zhirong Zou   +22 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Marine Protected Areas as Fishery Policy: A Discussion of the Potential Costs and Benefits [PDF]

Marine protected areas (MPAs) are currently receiving considerable attention as a "new" tool to control overexploitation. Many advocates argue that MPAs will provide a plethora of benefits ranging from improved habitat to higher fish stocks with little ...
Sanchirico, James
core  

The dietary patterns of water deer recently rediscovered in Northeast China exhibit remarkable similarities to those observed in other regions

Scientific Reports
Climate change, human activities, and habitat fragmentation—or even loss—pose ongoing threats to the survival of wildlife. Understanding the dietary habits of endangered species is a critical component of their conservation.
Zongzhi Li, Zhicheng Yao, Mingchun Zhang, Romaan Hayat Khattak, Xingzhi Han, Jia Sun, Zhongyu Li, Jianmin Lang, Chong Chen, Jing Jin, Zhensheng Liu, Liwei Teng   +11 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Demand for Vacations /Travel in Protected Areas – Dimension of Tourists’ Ecological Behavior [PDF]

Tourism, in itself, is one of the main users of the environment and, implicitly, an important contributor to its deterioration. Intensification of tourist travel will naturally generate an increase of the negative environmental impacts and, in the long ...
Remus Hornoiu, Mihaela Pădurean, Rodica Minciu, Delia Popescu   +3 more
core  

Thresholding species distribution models: Simple approaches for land‐use planning in multifunctional landscapes

Methods in Ecology and Evolution
Species distribution models (SDMs) are often used to understand changes to species' distributions and their habitats under different land‐use scenarios, enabling decision makers to prioritize areas for management efforts and balance environmental ...
Hossam Eldien Abdel Moniem, Chris Mallon, Brandon Allen, Carter Littlefair, Lionel Leston, Ermias Azeria, Aaron Petty, Danielle Pendlebury   +7 more
doaj   +1 more source