Results 91 to 100 of about 5,137,800 (295)

Interactions between host sex and seasonal changes shape the gut microbial communities of wild blue sheep (Pseudois nayaur)

Frontiers in Microbiology
The construction of gut microbial communities in wildlife is influenced by both environmental factors and host genetic background. However, the mechanisms through which these factors interact to shape microbial communities remain poorly understood.
Yaxin Dong, Zhirong Zhang, Zhaoling Zhu, Tianhua Hu, Junda Chen, Liwei Teng, Liwei Teng, Zhensheng Liu, Zhensheng Liu   +8 more
doaj   +1 more source

The Status of Wildlife in Protected Areas Compared to Non-Protected Areas of Kenya

PLoS ONE, 2009
نقوم بتجميع أكثر من 270 تعدادًا للحياة البرية في كينيا على مدار الثلاثين عامًا الماضية لمقارنة الاتجاهات في المتنزهات والمحميات الوطنية مع النظم الإيكولوجية المجاورة والاتجاهات على مستوى البلاد. تظهر الدراسة أهمية التمييز بين التغيرات التي يسببها الإنسان من التذبذبات السكانية الطبيعية المتعلقة بهطول الأمطار والعوامل البيئية.
David Western, Samantha Russell, Innes C. Cuthill   +2 more
openaire   +5 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reconciling conservation and development in Madagascar's rapidly-expanding protected area system [PDF]

, 2014
The creation and management of protected areas is our principal approach to conserving biodiversity worldwide. Management and governance models for these diverse institutions have become more pluralistic in recent decades, moving away from the ...
Gardner, Charlie J.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sicilian Protected Areas Among Tourist Exploitation and Environmental Guardianship [PDF]

This report pursues the objective to define the connection that ties exploitation of the environment quality in the protected areas and the opportunities of economic and tourist development.
Vito Genna
core  

Assessing the Impact of the World Conservation Strategy After 45 Years

Conservation
In 1980, the UNEP, IUCN, and WWF published the World Conservation Strategy (WCS). This was the first time that the United Nations, alongside an intergovernmental organization (IUCN) and NGO (WWF), identified a comprehensive set of global conservation ...
Nigel Dudley, Marc Hockings, Margaret Kinnaird, Kent H. Redford, John G. Robinson, Sue Stolton, Hannah L. Timmins, James E. M. Watson   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source