Results 71 to 80 of about 1,753,274 (299)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cycle tourism development in the Peak District National Park, United Kingdom [PDF]
, 2015 Protected areas are at the centre of nature-based tourism, which is increasingly popular across the world. As visitor numbers increase, so does awareness of the harmful effects that large crowds may have on both natural resources and individuals ...
Davies, Nicholas James +2 more
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Dispersal of larval and juvenile seabream: Implications for Mediterranean marine protected areas [PDF]
, 2015 In the marine context, information about dispersal is essential for the design of networks of marine protected areas (MPAs). Generally, most of the dispersal of demersal fishes is thought to be driven by the transport of eggs and larvae in currents, with
Calo A. +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Size matters: the value of small populations for wintering waterbirds [PDF]
, 2004 Protecting systematically selected areas of land is a major step towards biodiversity conservation worldwide. Indeed, the identification and designation of protected areas more often than not forms a core component of both national and international ...
Atkinson-Willes G. L. +26 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Behavioral shifts of reintroduced Milu deer Elaphurus davidianus in East Dongting lake of China
Scientific ReportsReintroduction is an important method for recovering endangered and rare species in their natural habitats. Understanding how these species adapt to new environments is essential for their conservation and population recovery.
Zhibin Cheng +12 more
doaj +1 more source
Aquaculture and Marine Protected Areas: Exploring Potential Opportunities and Synergies [PDF]
, 2017 This new publication, aims at exploring potential opportunities and synergies between aquaculture and conservation. Acknowledging that both aquaculture and MPA may benefit from each other in striving for global sustainable development, here are some of ...
Dan Laffoley +2 more
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