Results 71 to 80 of about 373,630 (305)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An integrated framework for developing ecological indicators of visitor use in protected areas

, 2008
Sustainable tourism is considered an appropriate use of many Australian protected areas. However, such use needs to be managed and the effectiveness of management needs to be assessed as overuse can adversely affect the natural environment.
Castley, Guy, Hill, Wendy, Pickering, Catherine   +2 more
core  

The Sicilian system of Protected Areas – Integrated planning and management policies for protected areas

, 2018
Currently the Sicilian system of protected areas appears to be extremely advanced with its 12% of territory protected by regional regulations versus the nationwide average of 11%, but it is also the most contradictory one.
Lotta, Francesca, Schilleci, Filippo
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Behavioral shifts of reintroduced Milu deer Elaphurus davidianus in East Dongting lake of China

Scientific Reports
Reintroduction is an important method for recovering endangered and rare species in their natural habitats. Understanding how these species adapt to new environments is essential for their conservation and population recovery.
Zhibin Cheng, Hong Zhang, Jialiang Ma, Chengmiao Feng, Wei Liu, Zhenyu Zhong, Qingyun Guo, Qingxun Zhang, Pan Zhang, Shumiao Zhang, Cheng Zong, Jiade Bai, Kun Cheng   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Reconciling conservation and development in Madagascar's rapidly-expanding protected area system [PDF]

, 2014
The creation and management of protected areas is our principal approach to conserving biodiversity worldwide. Management and governance models for these diverse institutions have become more pluralistic in recent decades, moving away from the ...
Gardner, Charlie J.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Current Practices in Monitoring and Reporting on Sustainability of Visitor Use of Protected Areas

, 2010
Many protected areas, especially national parks, have a dual function of preserving valued resources and realising the recreational values inherent within the area.
Carter, R W, Carter, R.W., Higginbottom, K., Higginbottom, K, Narayanan, Y, Moore, S., Rodger, K., Roger, K, Moore, Susan, Narayanan, Y.   +9 more
core  

Interactions between host sex and seasonal changes shape the gut microbial communities of wild blue sheep (Pseudois nayaur)

Frontiers in Microbiology
The construction of gut microbial communities in wildlife is influenced by both environmental factors and host genetic background. However, the mechanisms through which these factors interact to shape microbial communities remain poorly understood.
Yaxin Dong, Zhirong Zhang, Zhaoling Zhu, Tianhua Hu, Junda Chen, Liwei Teng, Liwei Teng, Zhensheng Liu, Zhensheng Liu   +8 more
doaj   +1 more source