Results 81 to 90 of about 373,630 (305)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Protected areas, wildlife conservation and local welfare [PDF]

The establishment and expansion of protected areas in Africa have been motivated by the aspiration of increased wildlife abundance. During the past decades, however, this practise has been subject to a massive debate.
Anne Borge Johannesen
core  

The Status of Wildlife in Protected Areas Compared to Non-Protected Areas of Kenya

PLoS ONE, 2009
نقوم بتجميع أكثر من 270 تعدادًا للحياة البرية في كينيا على مدار الثلاثين عامًا الماضية لمقارنة الاتجاهات في المتنزهات والمحميات الوطنية مع النظم الإيكولوجية المجاورة والاتجاهات على مستوى البلاد. تظهر الدراسة أهمية التمييز بين التغيرات التي يسببها الإنسان من التذبذبات السكانية الطبيعية المتعلقة بهطول الأمطار والعوامل البيئية.
David Western, Samantha Russell, Innes C. Cuthill   +2 more
openaire   +5 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Commercialization of Holidays in the Protected Natural Areas - Form of the Sustainable Development in Tourism [PDF]

Sustainable development of tourism in the protected areas should be regarded as a continuous improvement process in the management quality of the protected natural areas that are included in the tourist circuit as well as of the ecological tourism ...
Andreea Băltăreţu, Remus Hornoiu, Mihaela Pădurean, Rodica Minciu, Delia Popescu   +4 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Digital Observatory for Protected Areas (DOPA) Explorer 1.0 [PDF]

, 2015
The Digital Observatory for Protected Areas (DOPA) has been developed to support the European Union’s efforts in strengthening our capacity to mobilize and use biodiversity data, information and forecasts so that they are readily accessible to ...
Martinez-Lopez, Javier, Temperley, William, Bastin, Lucy, Dubois, Grégoire, Graziano, Mariagrazia, Bertzky, Bastian, Cottam, Andrew   +6 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Sicilian Protected Areas Among Tourist Exploitation and Environmental Guardianship [PDF]

This report pursues the objective to define the connection that ties exploitation of the environment quality in the protected areas and the opportunities of economic and tourist development.
Vito Genna
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source