Results 81 to 90 of about 1,753,274 (299)

Evidence-based Decision-making in Canada’s Protected Areas Organizations: Implications for Management Effectiveness [PDF]

, 2018
Aichi Biodiversity Target 19 calls on Parties to the United Nations Convention on Biological Diversity (CBD) to improve, share, transfer, and apply knowledge.
Beechey, Thomas J., Bocking, Stephen, Groulx, Mark W., Lemieux, Christopher J.   +3 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Marine Protected Areas in Fisheries Management [PDF]

The use of protected areas as a fishery management tool has been suggested as a hedge against management failures and variation in harvests. A stochastic bioeconomic model of a two-species fishery will be used to test the performance of protected areas ...
Greenville, Jared W., MacAulay, T. Gordon   +1 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Interactions between host sex and seasonal changes shape the gut microbial communities of wild blue sheep (Pseudois nayaur)

Frontiers in Microbiology
The construction of gut microbial communities in wildlife is influenced by both environmental factors and host genetic background. However, the mechanisms through which these factors interact to shape microbial communities remain poorly understood.
Yaxin Dong, Zhirong Zhang, Zhaoling Zhu, Tianhua Hu, Junda Chen, Liwei Teng, Liwei Teng, Zhensheng Liu, Zhensheng Liu   +8 more
doaj   +1 more source

Protected Areas

, 2010
Protected areas are composed of land, freshwater and marine areas set aside through legislation to protect representative examples of Canadas ecosystems. They are created and managed by the federal, provincial and territorial governments. A small but increasing number is also administered by Aboriginal governments and communities.
openaire   +1 more source

Protected areas land management [PDF]

, 2007
Protected areas contain some of the world’s most beautiful scenery and outstanding natural and cultural landscapes. They play a vital role in conservation of biodiversity, maintaining genetic resources and protecting important ecosystem functions.
Imykshenova, Erzhena
core  

The worldwide costs of marine protected areas [PDF]

, 2004
Declines in marine harvests, wildlife, and habitats have prompted calls at both the 2002 World Summit on Sustainable Development and the 2003 World Parks Congress for the establishment of a global system of marine protected areas (MPAs).
A. Balmford, Baum, C. J. McClean, C. M. Roberts, Green, Hutchings, Jackson, Myers, N. Hockley, P. Gravestock, Pandolfi, Pauly, Pauly, Roberts, Roberts, Sala   +15 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source