Results 81 to 90 of about 5,137,800 (295)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
jeffreyhanson/global-protected-areas: Developmental release
, 2016 Automatically download and clean global protected area ...
Jeff Hanson
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Developing a national approach to visitor data collection, management and use for protected areas: thoughts from Australian research and practice [PDF]
, 2008 Information on visitor numbers, activities, expectations and satisfaction is vital for protected areas managers on two counts: to assist in the provision of the services and facilities that visitors need and want; and to determine if managers have been ...
Griffin, T. +3 more
core
Community perceptions of protected areas and tourism amidst poverty
, 2022 Community perceptions of protected areas and tourism are increasingly viewed as an important determinant of the success of conservation in southern Africa. Consequently, the literature on community perceptions has burgeoned.
Edwin Muchapondwa +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Protected areas, wildlife conservation and local welfare [PDF]
The establishment and expansion of protected areas in Africa have been motivated by the aspiration of increased wildlife abundance. During the past decades, however, this practise has been subject to a massive debate.
Anne Borge Johannesen
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Commercialization of Holidays in the Protected Natural Areas - Form of the Sustainable Development in Tourism [PDF]
Sustainable development of tourism in the protected areas should be regarded as a continuous improvement process in the management quality of the protected natural areas that are included in the tourist circuit as well as of the ecological tourism ...
Andreea Băltăreţu +4 more
core
Indigenous tourism in protected areas: issues and possibilities
, 2008 Protected area managers increasingly recognise that the maintenance of both cultural and biological diversity is crucial for ensuring the resilience of social and ecological systems (Berkes, Colding, Folke, 2000).
Hyams, W. +3 more
core +1 more source