Results 81 to 90 of about 1,742,110 (296)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Interactions between host sex and seasonal changes shape the gut microbial communities of wild blue sheep (Pseudois nayaur)

Frontiers in Microbiology
The construction of gut microbial communities in wildlife is influenced by both environmental factors and host genetic background. However, the mechanisms through which these factors interact to shape microbial communities remain poorly understood.
Yaxin Dong, Zhirong Zhang, Zhaoling Zhu, Tianhua Hu, Junda Chen, Liwei Teng, Liwei Teng, Zhensheng Liu, Zhensheng Liu   +8 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Protected Areas

, 2010
Protected areas are composed of land, freshwater and marine areas set aside through legislation to protect representative examples of Canadas ecosystems. They are created and managed by the federal, provincial and territorial governments. A small but increasing number is also administered by Aboriginal governments and communities.
openaire   +1 more source

Changes in NDVI and human population in protected areas on the Tibetan Plateau [PDF]

, 2019
Understanding the Tibetan Plateau’s role in environmental change has gained increasing scientific attention in light of warming and changes in landmanagement.
Cusack, Conor F, Gillespie, Thomas W, Madson, Austin, Xue, Yongkang   +3 more
core   +1 more source

A regulation-based classification system for marine protected areas: A response to Dudley et al. [9] [PDF]

, 2017
Dudley et al. [9] commented on our paper [11], arguing that the current IUCN objective-based categorization of protected areas, which is also used in marine protected areas (MPAs), should not be abandoned and replaced by the new regulation-based ...
Agardy, Al-Abdulrazzak, Anthony Caro, Barbara Horta e Costa, Boonzaier, Carr, Costello, Day, Devillers, Dudley, Emanuel J. Gonçalves, Fitzsimons, Gustavo Franco, Horta e Costa, Joachim Claudet, Karim Erzini, Kearney   +16 more
core   +4 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Marine Protected Areas and Pelagic Fishing: The Case of the Chagos Archipelago [PDF]

, 2011
This editorial elaborates on the ramifications of the new Chagos Marine Reserve in the context of pelagic ...
Charles Sheppard
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Marine Protected Areas: Country Case Studies on Policy, Governance and Institutional Issues [PDF]

, 2011
This document presents case studies of the policy, governance and institutional issues of marine protected areas (MPAs) in South America (Northeastern)-Brazil; India, Palau and Senegal.
Christophe Breuil, Daniela C. Kalikoski, Kim Friedman, Marcelo Vasconcellos, Ramya Rajagopalan, Yimnang Golbuu   +5 more
core