Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Property, construction process and environment. Three elements of legal structure which regulate our right to housing : a strange causal link [PDF]
32 páginas.Trabajo de Curso de Experto Universitario en Derecho Español Impartido en Inglés: Estudio de Conjunto (2014/15). The fundamental object of analysis of the Project presented here is the relationship between Property and Environment, and the ...
Sierra Quero, Francisco José
core
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Quantum nanostructures in strongly spin-orbit coupled two-dimensional systems
Recent progress in experimental studies of low-dimensional systems with strong spin-orbit coupling poses a question on the effect of this coupling on the energy spectrum of electrons in semiconductor nanostructures.
D. D. Awschalom +7 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Fecal microbiota is essential for host health because it increases digestive effectiveness. The crane species Grus nigricollis (G. nigricollis) is considered to be near threatened. The fecal microbial composition of crane is less understood, particularly
Zhongbin Wang +9 more
doaj +1 more source
O objetivo deste trabalho foi avaliar o desenvolvimento vegetativo de diferentes porta-enxertos cítricos semeados em bandejas de isopor, em comparação com a semeadura em tubetes cônicos irrigados por capilaridade.
Paulo de Tarso Lima Teixeira +3 more
doaj +1 more source
Meeting the challenges of urban park management: A Study of Two Sites: a thesis completed and submitted in partial fulfilment of the requirements for the degree of Master of Philosophy in Resource and Environmental Planning, Massey University, Palmerston North, New Zealand [PDF]
There are key environmental and management issues relevant to protected areas and national parks apparent world-wide such as: management of environmental quality, biodiversity conservation, management of visitor use and impacts, allocation of access, law
Maling-Emana, Maria Theresa Salvacion
core
Toroidal qubits: naturally-decoupled quiet artificial atoms [PDF]
The requirements of quantum computations impose high demands on the level of qubit protection from perturbations; in particular, from those produced by the environment.
Chipouline, Arkadi +4 more
core +3 more sources

