Results 71 to 80 of about 386,008 (315)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Bioeconomic Analysis of Protected Area use in Fisheries Management [PDF]
The use of protected areas as a fishery management tool has been suggested as a hedge against management failures and variation in harvests. A stochastic bioeconomic model of a two-species fishery will be used to test the performance of protected areas ...
Greenville, Jared W. +1 more
core +1 more source
Prioritising bird species of special concern for monitoring and conservation action in protected areas Esther Anna Mostert. [PDF]
, 2012 Includes abstract.This thesis focused on developing an approach for prioritising Bird Species of Special Concern for conservation and monitoring action within the South African National Parks (SANParks). SANParks is in the process of developing a Species
Mostert, Esther Anna
core
Birds as tourism flagship species: a case study of tropical islands. [PDF]
, 2009 Species selected as flagships to promote conservation activities around the world are typically well known and charismatic mega-fauna. Unfortunately this limits the scope for applying the concept as some critical areas for biodiversity conservation, such
Veríssimo, Diogo +9 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Marine Protected Areas in Fisheries Management [PDF]
The use of protected areas as a fishery management tool has been suggested as a hedge against management failures and variation in harvests. A stochastic bioeconomic model of a two-species fishery will be used to test the performance of protected areas ...
Greenville, Jared W. +1 more
core +1 more source
Simulating range shifts of African mammals under predicted climate change: potential conservation and economic consequences [PDF]
, 2008 Simulated present-day ranges of 281 African mammal species were produced using climate-envelope models. This modeling approach was robust and was therefore used to simulate potential future ranges of 281 African mammals in response to nine future climate
Palmer, Georgina
core
Species-free species distribution models describe macroecological properties of protected area networks. [PDF]
, 2017 Among the greatest challenges facing the conservation of plants and animal species in protected areas are threats from a rapidly changing climate. An altered climate creates both challenges and opportunities for improving the management of protected ...
Jason L Robinson +7 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Can Rock-Rubble Groynes Support Similar Intertidal Ecological Communities to Natural Rocky Shores?
Land, 2020 Despite the global implementation of rock-rubble groyne structures, there is limited research investigating their ecology, much less than for other artificial coastal structures. Here we compare the intertidal ecology of urban (or semi-urban) rock-rubble
Paul Holloway, Richard Field
doaj +1 more source