Results 91 to 100 of about 1,612 (126)

The role of ALOX15 in inflammation-related diseases. [PDF]

open access: yesFront Immunol
Tang R   +5 more
europepmc   +1 more source

Alox8 knockout exacerbates imiquimod-induced psoriasis-like inflammation. [PDF]

open access: yesCell Death Dis
Palmer MA   +10 more
europepmc   +1 more source
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Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation

International Immunopharmacology, 2021
Specialized proresolving mediators are enzymatically oxygenated natural molecules derived from polyunsaturated fatty acids and are considered novel. These novel mediators include lipoxins from arachidonic acid, resolvins and protectins from omega-3 essential fatty acids, and new maresins.
Weon Ju Lee, Jinjoo Kang, Jun Young Kim
exaly   +3 more sources

Total synthesis of the antiinflammatory and proresolving protectin D1

Tetrahedron Letters, 2011
Stereoselective total synthesis of protectin D1 was completed through construction of the Z,E,E-triene structure by using the Suzuki coupling between the vinyl borane (C13–C22) and the vinyl iodide (C1–C12). The Z-enyne, the acetylene precursor of the vinyl borane was synthesized from optically active γ-TMS allylic alcohol in a straightforward way.
Narihito Ogawa, Yuichi Kobayashi
exaly   +2 more sources

Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date

Biochimie, 2014
There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non-cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects.
Thierry Durand   +2 more
exaly   +5 more sources

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

Journal of Allergy and Clinical Immunology, 2013
Protectin D1 (PD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3 fatty acid docosahexaenoic acid (DHA). Exogenous PD1 conferred protection against eosinophilic inflammation in animals with experimental asthma, although its endogenous cellular source and functions in human airways are of interest.We sought to ...
Tsuyoshi Oguma, Koichi Fukunaga
exaly   +3 more sources

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