Results 101 to 110 of about 1,612 (126)
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Total synthesis of the potent anti-inflammatory lipid mediator Protectin D1
Tetrahedron Letters, 2014Abstract The total synthesis of the potent anti-inflammatory lipid mediator Protectin D1 derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C10 and C17 were obtained via a chiral pool strategy from (4 R )-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane and 3,4- O -isopropylidene-2-deoxy- d -ribose, respectively.
Bernd W Spur, Ana R Rodríguez
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The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza [PDF]
Cell, 2013 Influenza A viruses are a major cause of mortality. Given the potential for future lethal pandemics, effective drugs are needed for the treatment of severe influenza such as that caused by H5N1 viruses. Using mediator lipidomics and bioactive lipid screen, we report that the omega-3 polyunsaturated fatty acid (PUFA)-derived lipid mediator protectin D1 (
Jun Katahira, , Shota Nakamura
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Irish Journal of Medical Science, 2022
Hashimoto's thyroiditis (HT) is one of the most prevalent autoimmune endocrine diseases and caused by the loss of immune tolerance for the thyroid gland. Many pathophysiological mechanisms were speculated about the development of HT. In our study, we aimed to reveal the relationship between HT and IL-10, MCP-1, IFNɤ, and PD1 levels and compare them ...
Mehmet Erdogan +2 more
exaly +4 more sources
Hashimoto's thyroiditis (HT) is one of the most prevalent autoimmune endocrine diseases and caused by the loss of immune tolerance for the thyroid gland. Many pathophysiological mechanisms were speculated about the development of HT. In our study, we aimed to reveal the relationship between HT and IL-10, MCP-1, IFNɤ, and PD1 levels and compare them ...
Mehmet Erdogan +2 more
exaly +4 more sources
International Immunopharmacology, 2021
Docosahexaenoic acid-derived protectin D1 (PD1) was identified critical in the resolution of inflammation in vivo, where it modulates the innate immune response and stimulates resolution. Acute pancreatitis (AP) is characterized by local pancreatic inflammation with mild forms whereas systemic inflammation with severe forms.
Zhiyang, Wu +12 more
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Docosahexaenoic acid-derived protectin D1 (PD1) was identified critical in the resolution of inflammation in vivo, where it modulates the innate immune response and stimulates resolution. Acute pancreatitis (AP) is characterized by local pancreatic inflammation with mild forms whereas systemic inflammation with severe forms.
Zhiyang, Wu +12 more
openaire +2 more sources
Proresolving Lipid Mediators Resolvin D1 and Protectin D1 Isomer Attenuate Neointimal Hyperplasia in the Rat Carotid Artery Balloon Injury Model [PDF]
Journal of Surgical Research, 2019 Specialized proresolving mediators from ω-3 polyunsaturated fatty acid may control resolution of inflammation. We evaluated the influence of two specialized proresolving mediators, resolvin D1 (RvD1) and protectin D1 isomer (PD1 iso) on neointimal hyperplasia after balloon injury.Sprague Dawley male rats at 12-14 wk of age were injured as a model of ...
Kota Yamamoto +2 more
exaly +3 more sources
Journal of Cardiovascular Translational Research, 2023
Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms.
Peng Zhang +5 more
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Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms.
Peng Zhang +5 more
openaire +2 more sources
ChemInform, 2014
AbstractThe UV and LC/MS‐MS data recorded on the synthetically prepared protectin D1 (I) match those of the endogenously produced material.
M. Aursnes +4 more
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AbstractThe UV and LC/MS‐MS data recorded on the synthetically prepared protectin D1 (I) match those of the endogenously produced material.
M. Aursnes +4 more
openaire +1 more source
Prostaglandins & Other Lipid Mediators
This study aimed to assess the predictive capacity of specialized pro-resolving mediators (SPMs) regarding the complexity and prognosis of coronary heart disease (CHD). Total of 602 CHD patients were included in this study and categorized into low-risk, medium-risk, and high-risk groups based on the Synergy Between Percutaneous Coronary Intervention ...
Yun-Fei, Wang, Xue-Tao, Zhu, Ze-Ping, Hu
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This study aimed to assess the predictive capacity of specialized pro-resolving mediators (SPMs) regarding the complexity and prognosis of coronary heart disease (CHD). Total of 602 CHD patients were included in this study and categorized into low-risk, medium-risk, and high-risk groups based on the Synergy Between Percutaneous Coronary Intervention ...
Yun-Fei, Wang, Xue-Tao, Zhu, Ze-Ping, Hu
openaire +2 more sources
Protectin D1 Improves Alveolar Barrier Breach After HCl-induced Acute Lung Injury
American Journal of Respiratory and Critical Care MedicineAbstract Rationale: Acute respiratory distress syndrome (ARDS) is a clinical syndrome of diffuse pulmonary inflammation and pulmonary edema leading to severe acute respiratory failure. Despite a mortality rate of ARDS estimated to be 25-40%, there is still no effective pharmacological therapy for ARDS.
H. Irie +4 more
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Protectin D1 Is A Self-Produced Regulator Of Human Eosinophil Functions
C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE, 2011Jun Miyata +8 more
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